IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain

• 資料種別: 博士論文
• タイトル: IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain
• 著者・編者: Iwasa, Takuma; Afroz, Shaista; Inoue, Miho; Arakaki, Rieko; Oshima, Masamitsu; Raju, Resmi; Waskitho, Arief; Inoue, Masahisa; Baba, Otto; Matsuka, Yoshizo
• 著者標目: Iwasa, Takuma; Afroz, Shaista; Inoue, Miho; Arakaki, Rieko; Oshima, Masamitsu; Raju, Resmi; Waskitho, Arief; Inoue, Masahisa; Baba, Otto; Matsuka, Yoshizo
• 出版事項: Elsevier
• 出版年月日等: 2019-03-20
• 出版年（W3CDTF）: 2019-03-20
• 並列タイトル等: 神経障害性疼痛における三叉神経筋内のIL-10とCXCL2
• タイトル（掲載誌）: Neuroscience Letters
• 巻号年月日等（掲載誌）: 703
• 掲載巻: 703
• 掲載ページ: 132-138
• ISSN（掲載誌）: ISSN : 0304-3940
• 授与機関名: 徳島大学
• 授与年月日: 2019-06-13
• 報告番号: 甲第3317号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Orofacial pain; Neuropathic pain; Sensory ganglia; Glial cell; Cytokine; Chemokine
• 対象利用者: 一般
• 一般注記: Many trigeminal neuropathic pain patients suffer severe chronic pain. The neuropathic pain might be related with cross-excitation of the neighboring neurons and satellite glial cell (SGCs) in the sensory ganglia and increasing the pain signals from the peripheral tissue to the central nervous system. We induced trigeminal neuropathic pain by infraorbital nerve constriction injury (IONC) in Sprague-Dawley rats. We tested cytokine (CXCL2 and IL-10) levels in trigeminal ganglia (TGs) after trigeminal neuropathic pain induction, and the effect of direct injection of the anti-CXCL2 and recombinant IL-10 into TG. We found that IONC induced pain behavior. Additionally, IONC induced satellite glial cell activation in TG and cytokine levels of TGs were changed after IONC. CXCL2 levels increased on day 1 of neuropathic pain induction and decreased gradually, with IL-10 levels showing the opposite trend. Recombinant IL-10 or anti-CXCL2 injection into TG decreased pain behavior. Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2019 Elsevier B.V. All rights reserved.
• 関連情報（DOI）: 10.1016/j.neulet.2019.03.031
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/113686/2019082917143397171/k3317_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113686/20190829171433702952/k3317_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113686/20190829171433999495/k3317_fulltext.pdf fulltext