IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain

• Material Type: 博士論文
• Title: IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain
• Author/Editor: Iwasa, Takuma; Afroz, Shaista; Inoue, Miho; Arakaki, Rieko; Oshima, Masamitsu; Raju, Resmi; Waskitho, Arief; Inoue, Masahisa; Baba, Otto; Matsuka, Yoshizo
• Author Heading: Iwasa, Takuma; Afroz, Shaista; Inoue, Miho; Arakaki, Rieko; Oshima, Masamitsu; Raju, Resmi; Waskitho, Arief; Inoue, Masahisa; Baba, Otto; Matsuka, Yoshizo
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2019-03-20
• Publication Date (W3CDTF): 2019-03-20
• Alternative Title: 神経障害性疼痛における三叉神経筋内のIL-10とCXCL2
• Periodical title: Neuroscience Letters
• No. or year of volume/issue: 703
• Volume: 703
• Pages: 132-138
• ISSN (Periodical Title): ISSN : 0304-3940
• Degree grantor/type: 徳島大学
• Date Granted: 2019-06-13
• Dissertation Number: 甲第3317号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Orofacial pain; Neuropathic pain; Sensory ganglia; Glial cell; Cytokine; Chemokine
• Target Audience: 一般
• Note (General): Many trigeminal neuropathic pain patients suffer severe chronic pain. The neuropathic pain might be related with cross-excitation of the neighboring neurons and satellite glial cell (SGCs) in the sensory ganglia and increasing the pain signals from the peripheral tissue to the central nervous system. We induced trigeminal neuropathic pain by infraorbital nerve constriction injury (IONC) in Sprague-Dawley rats. We tested cytokine (CXCL2 and IL-10) levels in trigeminal ganglia (TGs) after trigeminal neuropathic pain induction, and the effect of direct injection of the anti-CXCL2 and recombinant IL-10 into TG. We found that IONC induced pain behavior. Additionally, IONC induced satellite glial cell activation in TG and cytokine levels of TGs were changed after IONC. CXCL2 levels increased on day 1 of neuropathic pain induction and decreased gradually, with IL-10 levels showing the opposite trend. Recombinant IL-10 or anti-CXCL2 injection into TG decreased pain behavior. Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2019 Elsevier B.V. All rights reserved.
• Related Material (DOI): 10.1016/j.neulet.2019.03.031
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/113686/2019082917143397171/k3317_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113686/20190829171433702952/k3317_review.pdf fulltext

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