A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats

• 資料種別: 博士論文
• タイトル: A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats
• 著者・編者: Matsuda, Kazunori; Kitahara, Tadashi; Ito, Taeko; Fukushima, Munehisa; Fukuda, Junya; Sato, Go; Kitamura, Yoshiaki; Abe, Koji; Uno, Atsuhiko; Tomita, Koichi; Sakata-Haga, Hiromi; Fukui, Yoshihiro; Takeda, Noriaki
• 著者標目: Matsuda, Kazunori; Kitahara, Tadashi; Ito, Taeko; Fukushima, Munehisa; Fukuda, Junya; Sato, Go; Kitamura, Yoshiaki; Abe, Koji; Uno, Atsuhiko; Tomita, Koichi; Sakata-Haga, Hiromi; Fukui, Yoshihiro; Takeda, Noriaki
• 出版事項: Taylor & Francis
• 出版年月日等: 2019-04-16
• 出版年（W3CDTF）: 2019-04-16
• 並列タイトル等: 免疫組織化学法を用いた一側内耳破壊ラットの前庭代償の新しい評価法の開発
• タイトル（掲載誌）: Acta Oto-Laryngologica
• 巻号年月日等（掲載誌）: 139 6
• 掲載巻: 139
• 掲載号: 6
• 掲載ページ: 505-510
• ISSN（掲載誌）: ISSN : 0001-6489; ISSN : 1651-2251
• 授与機関名: 徳島大学
• 授与年月日: 2019-10-24
• 報告番号: 甲第3339号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Vestibular compensation; medial vestibular nucleus; spontaneous nystagmus; Fos; thioperamide; N-methyl-D-aspartate receptor
• 対象利用者: 一般
• 一般注記: Background: Unilateral labyrinthectomy (UL) causes the disappearance of ipsilateral medial vestibular nuclear (ipsi-MVe) activity and induces spontaneous nystagmus (SN), which disappears during the initial process of vestibular compensation (VC). Ipsi-MVe-activity restores in the late process of VC. Objective: We evaluated the late process of VC after UL in rats and examined the effects of thioperamide (H3 antagonist) on VC. Materials and methods: MK801 (NMDA antagonist)-induced Fos-like immunoreactive (-LIR) neurons in contra-MVe, which had been suppressed by NMDA-mediated cerebellar inhibition in UL-rats was used as an index. Results: The number of MK801-induced Fos-LIR neurons in contra-MVe gradually decreased to the same level as that of sham-operated rats 14 days after UL. Thioperamide moved the disappearance of the MK801-induced Fos-LIR neurons 2 days earlier. The number of MK801-induced Fos-LIR neurons in thioperamide-treated rats was significantly decreased, compared with that of vehicle-rats on days 7 and 12 after UL. But, thioperamide did not influence the decline of SN frequency in UL-rats. Conclusion: There findings suggested that the number of MK801-induced Fos-LIR neurons in contra-MVe was decreased in concordance with the restoration of ipsi-MVe-activity during the late process of VC after UL and that thioperamide accelerated the late, but not the initial process of VC.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1080/00016489.2019.1599140
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/113985/20191114145533680539/k3339_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113985/20191114145534172527/k3339_fulltext.pdf fulltext