A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats

• Material Type: 博士論文
• Title: A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats
• Author/Editor: Matsuda, Kazunori; Kitahara, Tadashi; Ito, Taeko; Fukushima, Munehisa; Fukuda, Junya; Sato, Go; Kitamura, Yoshiaki; Abe, Koji; Uno, Atsuhiko; Tomita, Koichi; Sakata-Haga, Hiromi; Fukui, Yoshihiro; Takeda, Noriaki
• Author Heading: Matsuda, Kazunori; Kitahara, Tadashi; Ito, Taeko; Fukushima, Munehisa; Fukuda, Junya; Sato, Go; Kitamura, Yoshiaki; Abe, Koji; Uno, Atsuhiko; Tomita, Koichi; Sakata-Haga, Hiromi; Fukui, Yoshihiro; Takeda, Noriaki
• Publication, Distribution, etc.: Taylor & Francis
• Publication Date: 2019-04-16
• Publication Date (W3CDTF): 2019-04-16
• Alternative Title: 免疫組織化学法を用いた一側内耳破壊ラットの前庭代償の新しい評価法の開発
• Periodical title: Acta Oto-Laryngologica
• No. or year of volume/issue: 139 6
• Volume: 139
• Issue: 6
• Pages: 505-510
• ISSN (Periodical Title): ISSN : 0001-6489; ISSN : 1651-2251
• Degree grantor/type: 徳島大学
• Date Granted: 2019-10-24
• Dissertation Number: 甲第3339号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Vestibular compensation; medial vestibular nucleus; spontaneous nystagmus; Fos; thioperamide; N-methyl-D-aspartate receptor
• Target Audience: 一般
• Note (General): Background: Unilateral labyrinthectomy (UL) causes the disappearance of ipsilateral medial vestibular nuclear (ipsi-MVe) activity and induces spontaneous nystagmus (SN), which disappears during the initial process of vestibular compensation (VC). Ipsi-MVe-activity restores in the late process of VC. Objective: We evaluated the late process of VC after UL in rats and examined the effects of thioperamide (H3 antagonist) on VC. Materials and methods: MK801 (NMDA antagonist)-induced Fos-like immunoreactive (-LIR) neurons in contra-MVe, which had been suppressed by NMDA-mediated cerebellar inhibition in UL-rats was used as an index. Results: The number of MK801-induced Fos-LIR neurons in contra-MVe gradually decreased to the same level as that of sham-operated rats 14 days after UL. Thioperamide moved the disappearance of the MK801-induced Fos-LIR neurons 2 days earlier. The number of MK801-induced Fos-LIR neurons in thioperamide-treated rats was significantly decreased, compared with that of vehicle-rats on days 7 and 12 after UL. But, thioperamide did not influence the decline of SN frequency in UL-rats. Conclusion: There findings suggested that the number of MK801-induced Fos-LIR neurons in contra-MVe was decreased in concordance with the restoration of ipsi-MVe-activity during the late process of VC after UL and that thioperamide accelerated the late, but not the initial process of VC.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1080/00016489.2019.1599140
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/113985/20191114145533680539/k3339_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113985/20191114145534172527/k3339_fulltext.pdf fulltext