Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions

• 資料種別: 博士論文
• タイトル: Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions
• 著者・編者: Oyama, Takuro; Kakuta, Nami; Mita, Naoji; Kawahito, Shinji; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• 著者標目: Oyama, Takuro; Kakuta, Nami; Mita, Naoji; Kawahito, Shinji; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• 出版事項: Elsevier|European Society for Clinical Nutrition and Metabolism
• 出版年月日等: 2018-04-10
• 出版年（W3CDTF）: 2018-04-10
• 並列タイトル等: 健康成人におけるゼリータイプの炭水化物サプリメント摂取は脂肪組織と筋蛋白質の異化を抑制し満足度を改善した
• タイトル（掲載誌）: Clinical Nutrition Experimental
• 巻号年月日等（掲載誌）: 19
• 掲載巻: 19
• 掲載ページ: 1-11
• ISSN（掲載誌）: ISSN : 2352-9393
• 授与機関名: 徳島大学
• 授与年月日: 2020-03-23
• 報告番号: 甲第3357号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Crossover design; Jelly-type oral nutritional supplement; Metabolism; Antioxidation; ERAS
• 対象利用者: 一般
• 一般注記: Background & aims: Many studies have reported the effects of preoperative clear fluid carbohydrate supplements; however, few studies have reported the effects of preoperative jelly-type carbohydrate supplements. This study aimed to assess the effect of a jelly-type oral nutritional supplement (ONS) on metabolism, redox balance by using various surrogate markers and to evaluate its excretion from the stomach. Methods: This study was conducted according to a crossover design. Participants underwent a control experiment whereby they fasted after dinner and only ingested water until the experiment. The remaining participants underwent an ONS experiment whereby they ingested 400 g of ONS before bed and another 400 g at 7:00 am. Blood samples were collected at 9:00 am. After a break of at least 24 h, participants underwent the alternate experiment. Results: Thirty minutes after intake of jelly, the gastric antrum appeared flat (the same result as that at baseline) on ultrasonography. The ONS group showed significantly lower serum free fatty acid levels (100 μEq/L, p = 0.027, vs. 327 μEq/L, n = 6), total ketone bodies levels, 3-MH/creatinine levels, and oxidative stress surrogate markers. Serum insulin levels were significantly higher and participant's satisfaction was improved in the ONS group. Conclusions: We have the limitations of our methodologies as surrogate markers, compared with direct measurement of lipolysis, proteolysis and redox balance regulation. But Jelly-type ONS suppresses the catabolism of adipose tissue and muscle protein, decreases oxidative stress and improves patient satisfaction in healthy participants, without any increased risk of aspiration.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2018 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• 関連情報（DOI）: 10.1016/j.yclnex.2018.04.002
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/114662/20200423093714439931/k3357_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114662/20200423093714923842/k3357_fulltext.pdf fulltext