Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions

• Material Type: 博士論文
• Title: Jelly-type carbohydrate supplement in healthy subjects suppresses the catabolism of adipose tissue and muscle protein and improves their satisfactions
• Author/Editor: Oyama, Takuro; Kakuta, Nami; Mita, Naoji; Kawahito, Shinji; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• Author Heading: Oyama, Takuro; Kakuta, Nami; Mita, Naoji; Kawahito, Shinji; Tanaka, Katsuya; Tsutsumi, Yasuo M.
• Publication, Distribution, etc.: Elsevier|European Society for Clinical Nutrition and Metabolism
• Publication Date: 2018-04-10
• Publication Date (W3CDTF): 2018-04-10
• Alternative Title: 健康成人におけるゼリータイプの炭水化物サプリメント摂取は脂肪組織と筋蛋白質の異化を抑制し満足度を改善した
• Periodical title: Clinical Nutrition Experimental
• No. or year of volume/issue: 19
• Volume: 19
• Pages: 1-11
• ISSN (Periodical Title): ISSN : 2352-9393
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Dissertation Number: 甲第3357号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Crossover design; Jelly-type oral nutritional supplement; Metabolism; Antioxidation; ERAS
• Target Audience: 一般
• Note (General): Background & aims: Many studies have reported the effects of preoperative clear fluid carbohydrate supplements; however, few studies have reported the effects of preoperative jelly-type carbohydrate supplements. This study aimed to assess the effect of a jelly-type oral nutritional supplement (ONS) on metabolism, redox balance by using various surrogate markers and to evaluate its excretion from the stomach. Methods: This study was conducted according to a crossover design. Participants underwent a control experiment whereby they fasted after dinner and only ingested water until the experiment. The remaining participants underwent an ONS experiment whereby they ingested 400 g of ONS before bed and another 400 g at 7:00 am. Blood samples were collected at 9:00 am. After a break of at least 24 h, participants underwent the alternate experiment. Results: Thirty minutes after intake of jelly, the gastric antrum appeared flat (the same result as that at baseline) on ultrasonography. The ONS group showed significantly lower serum free fatty acid levels (100 μEq/L, p = 0.027, vs. 327 μEq/L, n = 6), total ketone bodies levels, 3-MH/creatinine levels, and oxidative stress surrogate markers. Serum insulin levels were significantly higher and participant's satisfaction was improved in the ONS group. Conclusions: We have the limitations of our methodologies as surrogate markers, compared with direct measurement of lipolysis, proteolysis and redox balance regulation. But Jelly-type ONS suppresses the catabolism of adipose tissue and muscle protein, decreases oxidative stress and improves patient satisfaction in healthy participants, without any increased risk of aspiration.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2018 The Authors. Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• Related Material (DOI): 10.1016/j.yclnex.2018.04.002
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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