Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects

• 資料種別: 博士論文
• タイトル: Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects
• 著者・編者: Akita, Kazuya; Fukuda, Naoyuki; Kamada, Kumiko; Kudoh, Keiko; Kurio, Naito; Tsuru, Kanji; Ishikawa, Kunio; Miyamoto, Youji
• 著者標目: Akita, Kazuya; Fukuda, Naoyuki; Kamada, Kumiko; Kudoh, Keiko; Kurio, Naito; Tsuru, Kanji; Ishikawa, Kunio; Miyamoto, Youji
• 出版事項: Wiley
• 出版年月日等: 2019-11-22
• 出版年（W3CDTF）: 2019-11-22
• 並列タイトル等: マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発とウサギ頭蓋骨における組織学的評価
• タイトル（掲載誌）: Journal of Biomedical Materials Research Part A
• 巻号年月日等（掲載誌）: 108 3
• 掲載巻: 108
• 掲載号: 3
• 掲載ページ: 709-721
• ISSN（掲載誌）: ISSN : 1549-3296; ISSN : 1552-4965
• 授与機関名: 徳島大学
• 授与年月日: 2020-03-23
• 報告番号: 甲第3375号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: bone formation; bone substitute; carbonate apatite; hydroxyapatite; optimal pore size
• 対象利用者: 一般
• 一般注記: Carbonate apatite (CO3Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO3Ap granules through a two-step dissolution-precipitation reaction using CaSO4 as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO3Ap. Porous CO3Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO3Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO3Ap (120) [porous CO3Ap granules made using 120-μm microfiber] followed by CO3Ap (50) and CO3Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO3Ap (120). It is concluded, therefore, that the optimal pore size of the CO3Ap is that of CO3Ap (120), which is 85 μm.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1002/jbm.a.36850
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/114682/20200427135226253867/k3375_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114682/20200427135226961866/k3375_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114682/20200427135227274747/k3375_fulltext.pdf fulltext