Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects

• Material Type: 博士論文
• Title: Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects
• Author/Editor: Akita, Kazuya; Fukuda, Naoyuki; Kamada, Kumiko; Kudoh, Keiko; Kurio, Naito; Tsuru, Kanji; Ishikawa, Kunio; Miyamoto, Youji
• Author Heading: Akita, Kazuya; Fukuda, Naoyuki; Kamada, Kumiko; Kudoh, Keiko; Kurio, Naito; Tsuru, Kanji; Ishikawa, Kunio; Miyamoto, Youji
• Publication, Distribution, etc.: Wiley
• Publication Date: 2019-11-22
• Publication Date (W3CDTF): 2019-11-22
• Alternative Title: マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発とウサギ頭蓋骨における組織学的評価
• Periodical title: Journal of Biomedical Materials Research Part A
• No. or year of volume/issue: 108 3
• Volume: 108
• Issue: 3
• Pages: 709-721
• ISSN (Periodical Title): ISSN : 1549-3296; ISSN : 1552-4965
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Dissertation Number: 甲第3375号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: bone formation; bone substitute; carbonate apatite; hydroxyapatite; optimal pore size
• Target Audience: 一般
• Note (General): Carbonate apatite (CO3Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO3Ap granules through a two-step dissolution-precipitation reaction using CaSO4 as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO3Ap. Porous CO3Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO3Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO3Ap (120) [porous CO3Ap granules made using 120-μm microfiber] followed by CO3Ap (50) and CO3Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO3Ap (120). It is concluded, therefore, that the optimal pore size of the CO3Ap is that of CO3Ap (120), which is 85 μm.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1002/jbm.a.36850
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/114682/20200427135226253867/k3375_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114682/20200427135226961866/k3375_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114682/20200427135227274747/k3375_fulltext.pdf fulltext