Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis

• 資料種別: 博士論文
• タイトル: Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis
• 著者・編者: Kisoda, Satoru; Shao, Wenhua; Fujiwara, Natsumi; Mouri, Yasuhiro; Tsunematsu, Takaaki; Jin, Shengjian; Arakaki, Rieko; Ishimaru, Naozumi; Kudo, Yasusei
• 著者標目: Kisoda, Satoru; Shao, Wenhua; Fujiwara, Natsumi; Mouri, Yasuhiro; Tsunematsu, Takaaki; Jin, Shengjian; Arakaki, Rieko; Ishimaru, Naozumi; Kudo, Yasusei
• 出版事項: John Wiley & Sons
• 出版年月日等: 2020-04-11
• 出版年（W3CDTF）: 2020-04-11
• 並列タイトル等: 部分的上皮間葉転換関連遺伝子による頭頚部扁平上皮癌の予後予測; Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis; Prognostic value of p-EMT-related genes in HNSCC
• タイトル（掲載誌）: Oral Diseases
• 巻号年月日等（掲載誌）: 26 6
• 掲載巻: 26
• 掲載号: 6
• 掲載ページ: 1149-1156
• ISSN（掲載誌）: ISSN : 1601-0825
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-23
• 報告番号: 甲第3611号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Head and neck squamous cell carcinoma; Partial-epithelial-to-mesenchymal transition; prognosis
• 対象利用者: 一般
• 一般注記: Objective: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial EMT (p-EMT) poses a higher metastatic risk rather than complete EMT. Here we examined the prognostic value of p-EMT-related genes in head and neck squamous cell carcinoma (HNSCC) by bioinformatics approaches. Materials and Methods: We used RNA-seq data of 519 primary HNSCC cases obtained from TCGA database. We compared the expression of p-EMT-related genes in HNSCC tissues with normal tissues. We evaluated the prognostic value of p-EMT-related genes in HNSCC cases by Log-rank test. We examined the expression of p-EMT-, EMT-, and epithelial differentiation-related genes by qPCR. Results: Among p-EMT-related genes that were highly expressed in HNSCC cases, high expression of SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 was significantly correlated with poor survival of HNSCC patients. By gene expression pattern, HNSCC cell lines were classified into three groups; epithelial phenotype, EMT-phenotype, and p-EMT phenotype. Conclusions: Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: This is the peer reviewed version of the following article: Kisoda, S, Shao, W, Fujiwara, N, et al. Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis. Oral Dis. 2020; 26: 1149– 1156., which has been published in final form at https://doi.org/10.1111/odi.13351. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• 関連情報（DOI）: 10.1111/odi.13351
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/114969/20220426163426605877/k3611_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114969/20220426163426712754/k3611_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114969/20220426163426860424/k3611_fulltext.pdf fulltext