Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis

• Material Type: 博士論文
• Title: Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis
• Author/Editor: Kisoda, Satoru; Shao, Wenhua; Fujiwara, Natsumi; Mouri, Yasuhiro; Tsunematsu, Takaaki; Jin, Shengjian; Arakaki, Rieko; Ishimaru, Naozumi; Kudo, Yasusei
• Author Heading: Kisoda, Satoru; Shao, Wenhua; Fujiwara, Natsumi; Mouri, Yasuhiro; Tsunematsu, Takaaki; Jin, Shengjian; Arakaki, Rieko; Ishimaru, Naozumi; Kudo, Yasusei
• Publication, Distribution, etc.: John Wiley & Sons
• Publication Date: 2020-04-11
• Publication Date (W3CDTF): 2020-04-11
• Alternative Title: 部分的上皮間葉転換関連遺伝子による頭頚部扁平上皮癌の予後予測; Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis; Prognostic value of p-EMT-related genes in HNSCC
• Periodical title: Oral Diseases
• No. or year of volume/issue: 26 6
• Volume: 26
• Issue: 6
• Pages: 1149-1156
• ISSN (Periodical Title): ISSN : 1601-0825
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-23
• Dissertation Number: 甲第3611号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Head and neck squamous cell carcinoma; Partial-epithelial-to-mesenchymal transition; prognosis
• Target Audience: 一般
• Note (General): Objective: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial EMT (p-EMT) poses a higher metastatic risk rather than complete EMT. Here we examined the prognostic value of p-EMT-related genes in head and neck squamous cell carcinoma (HNSCC) by bioinformatics approaches. Materials and Methods: We used RNA-seq data of 519 primary HNSCC cases obtained from TCGA database. We compared the expression of p-EMT-related genes in HNSCC tissues with normal tissues. We evaluated the prognostic value of p-EMT-related genes in HNSCC cases by Log-rank test. We examined the expression of p-EMT-, EMT-, and epithelial differentiation-related genes by qPCR. Results: Among p-EMT-related genes that were highly expressed in HNSCC cases, high expression of SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 was significantly correlated with poor survival of HNSCC patients. By gene expression pattern, HNSCC cell lines were classified into three groups; epithelial phenotype, EMT-phenotype, and p-EMT phenotype. Conclusions: Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This is the peer reviewed version of the following article: Kisoda, S, Shao, W, Fujiwara, N, et al. Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis. Oral Dis. 2020; 26: 1149– 1156., which has been published in final form at https://doi.org/10.1111/odi.13351. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• Related Material (DOI): 10.1111/odi.13351
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/114969/20220426163426605877/k3611_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114969/20220426163426712754/k3611_review.pdf fulltext

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