Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization

• 資料種別: 博士論文
• タイトル: Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization
• 著者・編者: Liu, Yao; Xia, Linze; Kano, Fumiya; Hashimoto, Noboru; Matsuka, Yoshizo; Yamamoto, Akihito; Tanaka, Eiji
• 著者標目: Liu, Yao; Xia, Linze; Kano, Fumiya; Hashimoto, Noboru; Matsuka, Yoshizo; Yamamoto, Akihito; Tanaka, Eiji
• 出版事項: 四国歯学会
• 出版年月日等: 2021-09-08
• 出版年（W3CDTF）: 2021-09-08
• 並列タイトル等: 低出力超音波パルスは坐骨神経部分結紮によって引き起こされる神経障害性疼痛をマクロファージ極性制御を介して改善する; Ultrasound Ameliorates Neuropathic Pain
• タイトル（掲載誌）: Journal of Oral Health and Biosciences
• 巻号年月日等（掲載誌）: 34 1
• 掲載巻: 34
• 掲載号: 1
• 掲載ページ: 11-18
• ISSN（掲載誌）: ISSN : 2189-6682
• 授与機関名: 徳島大学
• 授与年月日: 2021-09-09
• 報告番号: 甲第3543号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Neuropathic pain; Low-intensity pulsed ultrasound; Macrophages; Anti-inflammation
• 対象利用者: 一般
• 一般注記: Inflammatory (M1-polarized) macrophages cause neuropathic pain (NP) after nerve injury through non-resolving neuroinflammation. However, increasing evidence suggests that converting M1 to anti-inflammatory M2 macrophages may rescue NP. In the present study, the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) was investigated in a partial sciatic nerve ligation (PSL)-induced NP model. Materials and Methods: Abnormal pain sensation, such as tactile allodynia, was caused by PSL. Immediately after PSL induction, the mice were subjected to LIPUS treatment for 20 min/day for 7 days. LIPUS was used at an average intensity of 60 mW/cm2 and a frequency of 1.5 MHz. Results: In the behavioral test, the LIPUS group showed a significant improvement in the PSL-induced hypersensitivity compared to the PSL group not exposed to LIPUS. We found an increasing number of M2 macrophages in the injured sciatic nerves after LIPUS exposure. LIPUS treatment decreased expression of pro-inflammatory microglial markers in spinal cord. Conclusions: Our data suggest that LIPUS has an anti-nociceptive effect by increasing anti-inflammatory M2 macrophage and may be a suitable therapeutic candidate for NP.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.20738/johb.34.1_11
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/116287/20211006151132609371/k3543_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116287/20211006151133190679/k3543_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116287/20211006151133499968/k3543_fulltext.pdf fulltext