Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization

• Material Type: 博士論文
• Title: Low-Intensity Pulsed Ultrasound Ameliorates Neuropathic Pain Induced by Partial Sciatic Nerve Ligation Via Regulating Macrophage Polarization
• Author/Editor: Liu, Yao; Xia, Linze; Kano, Fumiya; Hashimoto, Noboru; Matsuka, Yoshizo; Yamamoto, Akihito; Tanaka, Eiji
• Author Heading: Liu, Yao; Xia, Linze; Kano, Fumiya; Hashimoto, Noboru; Matsuka, Yoshizo; Yamamoto, Akihito; Tanaka, Eiji
• Publication, Distribution, etc.: 四国歯学会
• Publication Date: 2021-09-08
• Publication Date (W3CDTF): 2021-09-08
• Alternative Title: 低出力超音波パルスは坐骨神経部分結紮によって引き起こされる神経障害性疼痛をマクロファージ極性制御を介して改善する; Ultrasound Ameliorates Neuropathic Pain
• Periodical title: Journal of Oral Health and Biosciences
• No. or year of volume/issue: 34 1
• Volume: 34
• Issue: 1
• Pages: 11-18
• ISSN (Periodical Title): ISSN : 2189-6682
• Degree grantor/type: 徳島大学
• Date Granted: 2021-09-09
• Dissertation Number: 甲第3543号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Neuropathic pain; Low-intensity pulsed ultrasound; Macrophages; Anti-inflammation
• Target Audience: 一般
• Note (General): Inflammatory (M1-polarized) macrophages cause neuropathic pain (NP) after nerve injury through non-resolving neuroinflammation. However, increasing evidence suggests that converting M1 to anti-inflammatory M2 macrophages may rescue NP. In the present study, the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) was investigated in a partial sciatic nerve ligation (PSL)-induced NP model. Materials and Methods: Abnormal pain sensation, such as tactile allodynia, was caused by PSL. Immediately after PSL induction, the mice were subjected to LIPUS treatment for 20 min/day for 7 days. LIPUS was used at an average intensity of 60 mW/cm2 and a frequency of 1.5 MHz. Results: In the behavioral test, the LIPUS group showed a significant improvement in the PSL-induced hypersensitivity compared to the PSL group not exposed to LIPUS. We found an increasing number of M2 macrophages in the injured sciatic nerves after LIPUS exposure. LIPUS treatment decreased expression of pro-inflammatory microglial markers in spinal cord. Conclusions: Our data suggest that LIPUS has an anti-nociceptive effect by increasing anti-inflammatory M2 macrophage and may be a suitable therapeutic candidate for NP.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.20738/johb.34.1_11
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/116287/20211006151132609371/k3543_abstract.pdf fulltext

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