Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients

• 資料種別: 博士論文
• タイトル: Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients
• 著者・編者: Yanagihara, Rie; Yamamoto, Yuri; Kawakita, Takako; Noguchi, Hiroki; Yano, Yuya; Hayashi, Noriko; Ohta, Chiaki; Minato, Saki; Kamada, Shuhei; Aoki, Hidenori; Tamura, Kou; Masaki, Rie; Tachibana, Ayaka; Arakaki, Ryosuke; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• 著者標目: Yanagihara, Rie; Yamamoto, Yuri; Kawakita, Takako; Noguchi, Hiroki; Yano, Yuya; Hayashi, Noriko; Ohta, Chiaki; Minato, Saki; Kamada, Shuhei; Aoki, Hidenori; Tamura, Kou; Masaki, Rie; Tachibana, Ayaka; Arakaki, Ryosuke; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2022-02
• 出版年（W3CDTF）: 2022-02
• 並列タイトル等: Biotin levels in blood and follicular fluid; 血中および卵胞液中ビオチン濃度と体外受精/顕微授精患者における妊娠転帰との関連について
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 69 1-2
• 掲載巻: 69
• 掲載号: 1-2
• 掲載ページ: 65-69
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2024-03-22
• 報告番号: 甲第3792号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: biotin; IVF/ICSI; follicular fluid; pregnancy
• 対象利用者: 一般
• 一般注記: It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.69.65
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/117015/20240502102544419760/k3792_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117015/20240510091914901181/k3792_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117015/20240510091915216534/k3792_fulltext.pdf fulltext