Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients

• Material Type: 博士論文
• Title: Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients
• Author/Editor: Yanagihara, Rie; Yamamoto, Yuri; Kawakita, Takako; Noguchi, Hiroki; Yano, Yuya; Hayashi, Noriko; Ohta, Chiaki; Minato, Saki; Kamada, Shuhei; Aoki, Hidenori; Tamura, Kou; Masaki, Rie; Tachibana, Ayaka; Arakaki, Ryosuke; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• Author Heading: Yanagihara, Rie; Yamamoto, Yuri; Kawakita, Takako; Noguchi, Hiroki; Yano, Yuya; Hayashi, Noriko; Ohta, Chiaki; Minato, Saki; Kamada, Shuhei; Aoki, Hidenori; Tamura, Kou; Masaki, Rie; Tachibana, Ayaka; Arakaki, Ryosuke; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2022-02
• Publication Date (W3CDTF): 2022-02
• Alternative Title: Biotin levels in blood and follicular fluid; 血中および卵胞液中ビオチン濃度と体外受精/顕微授精患者における妊娠転帰との関連について
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 69 1-2
• Volume: 69
• Issue: 1-2
• Pages: 65-69
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-22
• Dissertation Number: 甲第3792号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: biotin; IVF/ICSI; follicular fluid; pregnancy
• Target Audience: 一般
• Note (General): It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.69.65
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/117015/20240502102544419760/k3792_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117015/20240510091914901181/k3792_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117015/20240510091915216534/k3792_fulltext.pdf fulltext