Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats

• 資料種別: 博士論文
• タイトル: Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats
• 著者・編者: Tokui, Takako; Kawakita, Takako; Yanagihara, Rie; Kamada, Shuhei; Minato, Saki; Takeda, Asuka; Imaizumi, Junki; Yamamoto, Yuri; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• 著者標目: Tokui, Takako; Kawakita, Takako; Yanagihara, Rie; Kamada, Shuhei; Minato, Saki; Takeda, Asuka; Imaizumi, Junki; Yamamoto, Yuri; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• 出版事項: Elsevier
• 出版年月日等: 2021-06-08
• 出版年（W3CDTF）: 2021-06-08
• 並列タイトル等: 雌ラットにおいて生殖腺の状態とエストロゲン環境が視床下部オキシトシン遺伝子発現および血清オキシトシンレベルに及ぼす影響
• タイトル（掲載誌）: Hormones and Behavior
• 巻号年月日等（掲載誌）: 133
• 掲載巻: 133
• 掲載ページ: 105005-
• ISSN（掲載誌）: ISSN : 0018-506X
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-23
• 報告番号: 甲第3592号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Oxytocin; Oxytocin receptor; Hypothalamus; Estradiol; Ovariectomy
• 対象利用者: 一般
• 一般注記: Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. In this study, we showed that ovariectomy decreased rats' hypothalamic OT/OTR mRNA and serum OT levels, but did not affect their visceral fat OTR mRNA levels. The chronic administration of estradiol (E2) abrogated these ovariectomy-induced changes; i.e., it increased the rats' hypothalamic OT/OTR mRNA and serum OT levels, and may be associated with reductions in food intake and body weight gain. In addition, acute E2 administration increased the rats' hypothalamic OTR mRNA and serum OT levels, but did not affect their hypothalamic OT mRNA levels. Taken together, these results suggest that endogenous OT and/or OTR expression might be positively regulated by E2 and that the suppressive effects of E2 on appetite and body weight gain might be mediated, at least in part, by the OT system. Thus, we consider that OT might be a target hormone to pursue subsequent interventions of menopause for menopause-induced metabolic disorders.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2021 Elsevier Inc.
• 関連情報（DOI）: 10.1016/j.yhbeh.2021.105005
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/116889/20220412142420933584/k3592_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116889/20220412142421458110/k3592_fulltext.pdf fulltext