Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats

• Material Type: 博士論文
• Title: Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats
• Author/Editor: Tokui, Takako; Kawakita, Takako; Yanagihara, Rie; Kamada, Shuhei; Minato, Saki; Takeda, Asuka; Imaizumi, Junki; Yamamoto, Yuri; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• Author Heading: Tokui, Takako; Kawakita, Takako; Yanagihara, Rie; Kamada, Shuhei; Minato, Saki; Takeda, Asuka; Imaizumi, Junki; Yamamoto, Yuri; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2021-06-08
• Publication Date (W3CDTF): 2021-06-08
• Alternative Title: 雌ラットにおいて生殖腺の状態とエストロゲン環境が視床下部オキシトシン遺伝子発現および血清オキシトシンレベルに及ぼす影響
• Periodical title: Hormones and Behavior
• No. or year of volume/issue: 133
• Volume: 133
• Pages: 105005-
• ISSN (Periodical Title): ISSN : 0018-506X
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-23
• Dissertation Number: 甲第3592号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Oxytocin; Oxytocin receptor; Hypothalamus; Estradiol; Ovariectomy
• Target Audience: 一般
• Note (General): Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. In this study, we showed that ovariectomy decreased rats' hypothalamic OT/OTR mRNA and serum OT levels, but did not affect their visceral fat OTR mRNA levels. The chronic administration of estradiol (E2) abrogated these ovariectomy-induced changes; i.e., it increased the rats' hypothalamic OT/OTR mRNA and serum OT levels, and may be associated with reductions in food intake and body weight gain. In addition, acute E2 administration increased the rats' hypothalamic OTR mRNA and serum OT levels, but did not affect their hypothalamic OT mRNA levels. Taken together, these results suggest that endogenous OT and/or OTR expression might be positively regulated by E2 and that the suppressive effects of E2 on appetite and body weight gain might be mediated, at least in part, by the OT system. Thus, we consider that OT might be a target hormone to pursue subsequent interventions of menopause for menopause-induced metabolic disorders.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): © 2021 Elsevier Inc.
• Related Material (DOI): 10.1016/j.yhbeh.2021.105005
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/116889/20220412142420933584/k3592_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116889/20220412142421458110/k3592_fulltext.pdf fulltext