Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling

• 資料種別: 博士論文
• タイトル: Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling
• 著者・編者: Yunizar, Mohammad Fadyl; Watanabe, Megumi; Liu, Lipei; Minami, Norikazu; Ichikawa, Tetsuo
• 著者標目: Yunizar, Mohammad Fadyl; Watanabe, Megumi; Liu, Lipei; Minami, Norikazu; Ichikawa, Tetsuo
• 出版事項: MDPI
• 出版年月日等: 2022-01-20
• 出版年（W3CDTF）: 2022-01-20
• 並列タイトル等: 金属アレルギーはTSLP-TSLPRシグナルを介して口腔扁平苔癬の発症に関与する
• タイトル（掲載誌）: Journal of Clinical Medicine
• 巻号年月日等（掲載誌）: 11 3
• 掲載巻: 11
• 掲載号: 3
• 掲載ページ: 519-
• ISSN（掲載誌）: ISSN : 2077-0383
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-23
• 報告番号: 甲第3613号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: metal allergy; oral lichen planus; TSLP-TSLPR
• 対象利用者: 一般
• 一般注記: Metal allergy is a T-cell-mediated delayed type of hypersensitive reaction. The pathogenetic mechanisms underlying the allergy are unclear, although the condition has been reported to be related to oral lichen planus (OLP), despite an absence of immunological studies to support this relationship. In this study, histopathological samples of OLP patients were examined to compare the metal allergy-positive and -negative groups, with a focus on the network of epidermal keratinocytes and T cells induced by thymic stromal lymphopoietin (TSLP) and its receptor, TSLPR. Infiltration of T cells into the epithelium was revealed to be higher in the OLP lesions of metal allergy-positive patients than in those of metal allergy-negative patients. Moreover, TSLP-TSLPR signaling and TNF-α production were higher in the epithelial tissue samples of the metal allergy-positive patients than in the metal allergy-negative patients. Metal allergy is associated with both increased expressions of TSLP in keratinocytes and increased TNF-α levels in the epithelium. We propose that this would promote the accumulation of T cells at the lesion site, contributing to the formation of the disease. These results suggest that metal allergy may be an aggravating factor in the pathogenesis of OLP.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• 関連情報（DOI）: 10.3390/jcm11030519
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/117036/20220517103531184849/k3613_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117036/20220517103531274836/k3613_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117036/20220517103531422214/k3613_fulltext.pdf fulltext