Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling

• Material Type: 博士論文
• Title: Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling
• Author/Editor: Yunizar, Mohammad Fadyl; Watanabe, Megumi; Liu, Lipei; Minami, Norikazu; Ichikawa, Tetsuo
• Author Heading: Yunizar, Mohammad Fadyl; Watanabe, Megumi; Liu, Lipei; Minami, Norikazu; Ichikawa, Tetsuo
• Publication, Distribution, etc.: MDPI
• Publication Date: 2022-01-20
• Publication Date (W3CDTF): 2022-01-20
• Alternative Title: 金属アレルギーはTSLP-TSLPRシグナルを介して口腔扁平苔癬の発症に関与する
• Periodical title: Journal of Clinical Medicine
• No. or year of volume/issue: 11 3
• Volume: 11
• Issue: 3
• Pages: 519-
• ISSN (Periodical Title): ISSN : 2077-0383
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-23
• Dissertation Number: 甲第3613号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: metal allergy; oral lichen planus; TSLP-TSLPR
• Target Audience: 一般
• Note (General): Metal allergy is a T-cell-mediated delayed type of hypersensitive reaction. The pathogenetic mechanisms underlying the allergy are unclear, although the condition has been reported to be related to oral lichen planus (OLP), despite an absence of immunological studies to support this relationship. In this study, histopathological samples of OLP patients were examined to compare the metal allergy-positive and -negative groups, with a focus on the network of epidermal keratinocytes and T cells induced by thymic stromal lymphopoietin (TSLP) and its receptor, TSLPR. Infiltration of T cells into the epithelium was revealed to be higher in the OLP lesions of metal allergy-positive patients than in those of metal allergy-negative patients. Moreover, TSLP-TSLPR signaling and TNF-α production were higher in the epithelial tissue samples of the metal allergy-positive patients than in the metal allergy-negative patients. Metal allergy is associated with both increased expressions of TSLP in keratinocytes and increased TNF-α levels in the epithelium. We propose that this would promote the accumulation of T cells at the lesion site, contributing to the formation of the disease. These results suggest that metal allergy may be an aggravating factor in the pathogenesis of OLP.
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Rights (production): This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• Related Material (DOI): 10.3390/jcm11030519
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/117036/20220517103531184849/k3613_abstract.pdf fulltext

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