Is a freeze-all strategy necessary for all embryo transfers : Fresh embryo transfer without progesterone elevation results in an equivalent pregnancy rate to cryopreserved embryo transfer

• 資料種別: 博士論文
• タイトル: Is a freeze-all strategy necessary for all embryo transfers : Fresh embryo transfer without progesterone elevation results in an equivalent pregnancy rate to cryopreserved embryo transfer
• 著者・編者: Abe, Masami; Yamamoto, Yuri; Noguchi, Hiroki; Tamura, Kou; Aoki, Hidenori; Takeda, Asuka; Minato, Saki; Kamada, Shuhei; Tachibana, Ayaka; Iwasa, Takeshi
• 著者標目: Abe, Masami; Yamamoto, Yuri; Noguchi, Hiroki; Tamura, Kou; Aoki, Hidenori; Takeda, Asuka; Minato, Saki; Kamada, Shuhei; Tachibana, Ayaka; Iwasa, Takeshi
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2022-08
• 出版年（W3CDTF）: 2022-08
• 並列タイトル等: すべての胚移植に全胚凍結法が必要か。プロゲステロン上昇を伴わない新鮮胚移植は、凍結融解胚移植と同等の妊娠率をもたらす; A freeze-all strategy is not necessary for all embryo transfers
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 69 3-4
• 掲載巻: 69
• 掲載号: 3-4
• 掲載ページ: 224-229
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2022-07-28
• 報告番号: 甲第3645号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: freeze-all; fresh embryo transfer; progesterone level
• 対象利用者: 一般
• 一般注記: Objectives : It has been suggested that the clinical outcomes of frozen-thawed embryo transfer (ET) are superior to those of fresh embryo transfer. We examined whether a freeze-all strategy is necessary for all embryo transfers, and, if not, to evaluate the conditions in which the pregnancy rates of fresh embryo transfer and frozen-thawed ET did not differ. Methods : Patients who underwent blastocyst transfer at Tokushima University Hospital between 2008 and 2019 were enrolled. The clinical outcomes and clinical characteristics of 1,022 patients that underwent fresh embryo transfer and 1,728 patients that underwent frozen-thawed ET were examined retrospectively. We considered the factors that influenced the pregnancy outcomes of fresh embryo transfer. Results : The frozen-thawed ET group exhibited significantly higher pregnancy, live-birth, and miscarriage rates than the fresh embryo transfer group. In the fresh embryo transfer group, a high progesterone level on the day of the human chorionic gonadotropin (hCG) trigger and lower grade embryos were risk factors for a low pregnancy rate. However, in the cases in which the progesterone level was < 1.0 ng / mL the pregnancy rate was equal to that of frozen-thawed ET. Conclusions : A freeze-all strategy is not necessary for embryo transfers, but should be employed in cases involving pre-ovulatory progesterone elevation.
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.69.224
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/117377/20220824105855185218/k3645_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117377/20220824105855447589/k3645_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117377/20221018161025289410/k3645_fulltext.pdf fulltext