Is a freeze-all strategy necessary for all embryo transfers : Fresh embryo transfer without progesterone elevation results in an equivalent pregnancy rate to cryopreserved embryo transfer

• Material Type: 博士論文
• Title: Is a freeze-all strategy necessary for all embryo transfers : Fresh embryo transfer without progesterone elevation results in an equivalent pregnancy rate to cryopreserved embryo transfer
• Author/Editor: Abe, Masami; Yamamoto, Yuri; Noguchi, Hiroki; Tamura, Kou; Aoki, Hidenori; Takeda, Asuka; Minato, Saki; Kamada, Shuhei; Tachibana, Ayaka; Iwasa, Takeshi
• Author Heading: Abe, Masami; Yamamoto, Yuri; Noguchi, Hiroki; Tamura, Kou; Aoki, Hidenori; Takeda, Asuka; Minato, Saki; Kamada, Shuhei; Tachibana, Ayaka; Iwasa, Takeshi
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2022-08
• Publication Date (W3CDTF): 2022-08
• Alternative Title: すべての胚移植に全胚凍結法が必要か。プロゲステロン上昇を伴わない新鮮胚移植は、凍結融解胚移植と同等の妊娠率をもたらす; A freeze-all strategy is not necessary for all embryo transfers
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 69 3-4
• Volume: 69
• Issue: 3-4
• Pages: 224-229
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2022-07-28
• Dissertation Number: 甲第3645号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: freeze-all; fresh embryo transfer; progesterone level
• Target Audience: 一般
• Note (General): Objectives : It has been suggested that the clinical outcomes of frozen-thawed embryo transfer (ET) are superior to those of fresh embryo transfer. We examined whether a freeze-all strategy is necessary for all embryo transfers, and, if not, to evaluate the conditions in which the pregnancy rates of fresh embryo transfer and frozen-thawed ET did not differ. Methods : Patients who underwent blastocyst transfer at Tokushima University Hospital between 2008 and 2019 were enrolled. The clinical outcomes and clinical characteristics of 1,022 patients that underwent fresh embryo transfer and 1,728 patients that underwent frozen-thawed ET were examined retrospectively. We considered the factors that influenced the pregnancy outcomes of fresh embryo transfer. Results : The frozen-thawed ET group exhibited significantly higher pregnancy, live-birth, and miscarriage rates than the fresh embryo transfer group. In the fresh embryo transfer group, a high progesterone level on the day of the human chorionic gonadotropin (hCG) trigger and lower grade embryos were risk factors for a low pregnancy rate. However, in the cases in which the progesterone level was < 1.0 ng / mL the pregnancy rate was equal to that of frozen-thawed ET. Conclusions : A freeze-all strategy is not necessary for embryo transfers, but should be employed in cases involving pre-ovulatory progesterone elevation.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.69.224
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/117377/20220824105855185218/k3645_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117377/20220824105855447589/k3645_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117377/20221018161025289410/k3645_fulltext.pdf fulltext