All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal

• 資料種別: 博士論文
• タイトル: All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal
• 著者・編者: Adachi, Yuichiro; Masuda, Masashi; Sakakibara, Iori; Uchida, Takayuki; Niida, Yuki; Mori, Yuki; Kamei, Yuki; Okumura, Yosuke; Ohminami, Hirokazu; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Nikawa, Takeshi; Taketani, Yutaka
• 著者標目: Adachi, Yuichiro; Masuda, Masashi; Sakakibara, Iori; Uchida, Takayuki; Niida, Yuki; Mori, Yuki; Kamei, Yuki; Okumura, Yosuke; Ohminami, Hirokazu; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Nikawa, Takeshi; Taketani, Yutaka
• 出版事項: Life Science Alliance
• 出版年月日等: 2022-03-22
• 出版年（W3CDTF）: 2022-03-22
• 並列タイトル等: 全トランスレチノイン酸はMAPKシグナル依存的なGADD34の増加を介して筋繊維タイプを変化させる; Increase of GADD34 expression in skeletal muscle by ATRA
• タイトル（掲載誌）: Life Science Alliance
• 巻号年月日等（掲載誌）: 5 7
• 掲載巻: 5
• 掲載号: 7
• 掲載ページ: e202101345-
• ISSN（掲載誌）: ISSN : 2575-1077
• 授与機関名: 徳島大学
• 授与年月日: 2023-03-23
• 報告番号: 甲第3707号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: MAPK; mRNA stabilization; skeletal muscle type change; transcription; unfolded protein response
• 対象利用者: 一般
• 一般注記: All-trans retinoic acid (ATRA) increases the sensitivity to unfolded protein response in differentiating leukemic blasts. The downstream transcriptional factor of PERK, a major arm of unfolded protein response, regulates muscle differentiation. However, the role of growth arrest and DNA damage-inducible protein 34 (GADD34), one of the downstream factors of PERK, and the effects of ATRA on GADD34 expression in muscle remain unclear. In this study, we identified ATRA increased the GADD34 expression independent of the PERK signal in the gastrocnemius muscle of mice. ATRA up-regulated GADD34 expression through the transcriptional activation of GADD34 gene via inhibiting the interaction of homeobox Six1 and transcription co-repressor TLE3 with the MEF3-binding site on the GADD34 gene promoter in skeletal muscle. ATRA also inhibited the interaction of TTP, which induces mRNA degradation, with AU-rich element on GADD34 mRNA via p-38 MAPK, resulting in the instability of GADD34 mRNA. Overexpressed GADD34 in C2C12 cells changes the type of myosin heavy chain in myotubes. These results suggest ATRA increases GADD34 expression via transcriptional and post-transcriptional regulation, which changes muscle fiber type.
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
• 関連情報（DOI）: 10.26508/lsa.202101345
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/117429/20230607152152465777/k3707_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117429/20230607152152918967/k3707_fulltext.pdf fulltext