All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal

• Material Type: 博士論文
• Title: All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal
• Author/Editor: Adachi, Yuichiro; Masuda, Masashi; Sakakibara, Iori; Uchida, Takayuki; Niida, Yuki; Mori, Yuki; Kamei, Yuki; Okumura, Yosuke; Ohminami, Hirokazu; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Nikawa, Takeshi; Taketani, Yutaka
• Author Heading: Adachi, Yuichiro; Masuda, Masashi; Sakakibara, Iori; Uchida, Takayuki; Niida, Yuki; Mori, Yuki; Kamei, Yuki; Okumura, Yosuke; Ohminami, Hirokazu; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Nikawa, Takeshi; Taketani, Yutaka
• Publication, Distribution, etc.: Life Science Alliance
• Publication Date: 2022-03-22
• Publication Date (W3CDTF): 2022-03-22
• Alternative Title: 全トランスレチノイン酸はMAPKシグナル依存的なGADD34の増加を介して筋繊維タイプを変化させる; Increase of GADD34 expression in skeletal muscle by ATRA
• Periodical title: Life Science Alliance
• No. or year of volume/issue: 5 7
• Volume: 5
• Issue: 7
• Pages: e202101345-
• ISSN (Periodical Title): ISSN : 2575-1077
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-23
• Dissertation Number: 甲第3707号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: MAPK; mRNA stabilization; skeletal muscle type change; transcription; unfolded protein response
• Target Audience: 一般
• Note (General): All-trans retinoic acid (ATRA) increases the sensitivity to unfolded protein response in differentiating leukemic blasts. The downstream transcriptional factor of PERK, a major arm of unfolded protein response, regulates muscle differentiation. However, the role of growth arrest and DNA damage-inducible protein 34 (GADD34), one of the downstream factors of PERK, and the effects of ATRA on GADD34 expression in muscle remain unclear. In this study, we identified ATRA increased the GADD34 expression independent of the PERK signal in the gastrocnemius muscle of mice. ATRA up-regulated GADD34 expression through the transcriptional activation of GADD34 gene via inhibiting the interaction of homeobox Six1 and transcription co-repressor TLE3 with the MEF3-binding site on the GADD34 gene promoter in skeletal muscle. ATRA also inhibited the interaction of TTP, which induces mRNA degradation, with AU-rich element on GADD34 mRNA via p-38 MAPK, resulting in the instability of GADD34 mRNA. Overexpressed GADD34 in C2C12 cells changes the type of myosin heavy chain in myotubes. These results suggest ATRA increases GADD34 expression via transcriptional and post-transcriptional regulation, which changes muscle fiber type.
• Access Restrictions: インターネット公開
• Rights (production): This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
• Related Material (DOI): 10.26508/lsa.202101345
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/117429/20230607152152465777/k3707_abstract_review.pdf fulltext

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