Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes

• 資料種別: 博士論文
• タイトル: Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes
• 著者・編者: Kawakami, Ayuka; Bando, Mika; Takashi, Tomoe; Sugiuchi, Mizuki; Hyodo, Mizusa; Mishima, Yuna; Kuroda, Masashi; Mori, Hiroyasu; Kuroda, Akio; Yumoto, Hiromichi; Matsuhisa, Munehide; Sakaue, Hiroshi; Tsutsumi, Rie
• 著者標目: Kawakami, Ayuka; Bando, Mika; Takashi, Tomoe; Sugiuchi, Mizuki; Hyodo, Mizusa; Mishima, Yuna; Kuroda, Masashi; Mori, Hiroyasu; Kuroda, Akio; Yumoto, Hiromichi; Matsuhisa, Munehide; Sakaue, Hiroshi; Tsutsumi, Rie
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2023-02
• 出版年（W3CDTF）: 2023-02
• 並列タイトル等: 糖尿病患者におけるうま味味覚感度は食品摂取と口腔内環境に関連する; Umami taste sensitivity in diabetes
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 70 1-2
• 掲載巻: 70
• 掲載号: 1-2
• 掲載ページ: 241-250
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2023-03-23
• 報告番号: 甲第3708号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: Umami; taste sensitivity; Diabetes; Food intake; Oral environments
• 対象利用者: 一般
• 一般注記: Objective : Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This study aimed to investigate the association between taste sensitivity, eating habits, and the oral environment. Subjects and methods : In this cross-sectional study of 75 subjects with diabetes, gustatory function was assessed using the whole-mouth method, and lingual taste receptor gene expression was measured by real-time PCR. Food intake was evaluated using a food frequency questionnaire based on food groups. The oral environment was assessed using xerostomia and periodontal comprehensive examination. Results : In total, 45.3%, 28.0%, and 18.7% of subjects showed lower umami taste sensitivity, low sweet taste sensitivity, and low salt taste sensitivity, respectively. Lower umami sensitivity correlated with lower estimated glomerular filtration rate and higher energy-source food intake. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression than those with lower plaque control record. Conclusion : Reduced umami taste sensitivity is associated with decreased renal function and high energy food intake in diabetes. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression, suggesting that the oral environment affects taste gene expression.
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.70.241
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/118208/20230512145656844277/k3708_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118208/20230512145657136330/k3708_fulltext.pdf fulltext