Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes

• Material Type: 博士論文
• Title: Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes
• Author/Editor: Kawakami, Ayuka; Bando, Mika; Takashi, Tomoe; Sugiuchi, Mizuki; Hyodo, Mizusa; Mishima, Yuna; Kuroda, Masashi; Mori, Hiroyasu; Kuroda, Akio; Yumoto, Hiromichi; Matsuhisa, Munehide; Sakaue, Hiroshi; Tsutsumi, Rie
• Author Heading: Kawakami, Ayuka; Bando, Mika; Takashi, Tomoe; Sugiuchi, Mizuki; Hyodo, Mizusa; Mishima, Yuna; Kuroda, Masashi; Mori, Hiroyasu; Kuroda, Akio; Yumoto, Hiromichi; Matsuhisa, Munehide; Sakaue, Hiroshi; Tsutsumi, Rie
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2023-02
• Publication Date (W3CDTF): 2023-02
• Alternative Title: 糖尿病患者におけるうま味味覚感度は食品摂取と口腔内環境に関連する; Umami taste sensitivity in diabetes
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 70 1-2
• Volume: 70
• Issue: 1-2
• Pages: 241-250
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-23
• Dissertation Number: 甲第3708号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: Umami; taste sensitivity; Diabetes; Food intake; Oral environments
• Target Audience: 一般
• Note (General): Objective : Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This study aimed to investigate the association between taste sensitivity, eating habits, and the oral environment. Subjects and methods : In this cross-sectional study of 75 subjects with diabetes, gustatory function was assessed using the whole-mouth method, and lingual taste receptor gene expression was measured by real-time PCR. Food intake was evaluated using a food frequency questionnaire based on food groups. The oral environment was assessed using xerostomia and periodontal comprehensive examination. Results : In total, 45.3%, 28.0%, and 18.7% of subjects showed lower umami taste sensitivity, low sweet taste sensitivity, and low salt taste sensitivity, respectively. Lower umami sensitivity correlated with lower estimated glomerular filtration rate and higher energy-source food intake. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression than those with lower plaque control record. Conclusion : Reduced umami taste sensitivity is associated with decreased renal function and high energy food intake in diabetes. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression, suggesting that the oral environment affects taste gene expression.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.70.241
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/118208/20230512145656844277/k3708_abstract_review.pdf fulltext

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