Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen

• 資料種別: 博士論文
• タイトル: Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen
• 著者・編者: Sumida, Satoshi; Ichimura-Shimizu, Mayuko; Miyakami, Yuko; Kakimoto, Takumi; Kobayashi, Tomoko; Saijo, Yasuyo; Matsumoto, Minoru; Ogawa, Hirohisa; Oya, Takeshi; Bando, Yoshimi; Uehara, Hisanori; Taira, Shu; Shimada, Mitsuo; Tsuneyama, Koichi
• 著者標目: Sumida, Satoshi; Ichimura-Shimizu, Mayuko; Miyakami, Yuko; Kakimoto, Takumi; Kobayashi, Tomoko; Saijo, Yasuyo; Matsumoto, Minoru; Ogawa, Hirohisa; Oya, Takeshi; Bando, Yoshimi; Uehara, Hisanori; Taira, Shu; Shimada, Mitsuo; Tsuneyama, Koichi
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2023-02
• 出版年（W3CDTF）: 2023-02
• 並列タイトル等: 膵内副脾発生類表皮嚢胞の発生機序・組織学的特徴に関する検討; Histological analysis of ECIPAS
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 70 1-2
• 掲載巻: 70
• 掲載号: 1-2
• 掲載ページ: 251-259
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2023-03-23
• 報告番号: 甲第3702号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Epidermoid cyst in intrapancreatic accessory spleen; imaging mass spectrometry; lipid excretion; Pbx1; Tlx1
• 対象利用者: 一般
• 一般注記: Background : Epidermoid cysts in intrapancreatic accessory spleen (ECIPAS) are a rare lesion. Its pathogenesis, including the origin of cystic epithelium, is not well established. We aimed to elucidate new aspects of the pathological features of ECIPAS to clarify its pathogenesis. Methods : Six cases of ECIPAS were included in this study. As well as histopathological analysis, to elucidate the features and nature of cystic epithelial cells, immunohistochemical analysis including Pbx1 and Tlx1 and imaging mass spectrometry was performed. Results : Histologically, the cysts were covered by either monolayered or multilayered epithelium. Immunohistochemistry revealed that the epithelial cells in multilayered epithelium exhibited different attributes between the basal and superficial layers. Few epithelial cells had abundant clear cytoplasm and were immunohistochemically positive for adipophilin, suggesting lipid-excreting function. The intracystic fluid contained cholesterol clefts and foamy macrophages, and imaging mass spectrometry revealed the accumulation of lipids. Immunohistochemical analysis indicated that the epithelial cells were positive for Pbx1 in some cases. Conclusion : Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin.
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.70.251
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/118205/20230511175750671675/k3702_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118205/20230511175750968782/k3702_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118205/20231201111524549499/k3702_fulltext.pdf fulltext