Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen

• Material Type: 博士論文
• Title: Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen
• Author/Editor: Sumida, Satoshi; Ichimura-Shimizu, Mayuko; Miyakami, Yuko; Kakimoto, Takumi; Kobayashi, Tomoko; Saijo, Yasuyo; Matsumoto, Minoru; Ogawa, Hirohisa; Oya, Takeshi; Bando, Yoshimi; Uehara, Hisanori; Taira, Shu; Shimada, Mitsuo; Tsuneyama, Koichi
• Author Heading: Sumida, Satoshi; Ichimura-Shimizu, Mayuko; Miyakami, Yuko; Kakimoto, Takumi; Kobayashi, Tomoko; Saijo, Yasuyo; Matsumoto, Minoru; Ogawa, Hirohisa; Oya, Takeshi; Bando, Yoshimi; Uehara, Hisanori; Taira, Shu; Shimada, Mitsuo; Tsuneyama, Koichi
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2023-02
• Publication Date (W3CDTF): 2023-02
• Alternative Title: 膵内副脾発生類表皮嚢胞の発生機序・組織学的特徴に関する検討; Histological analysis of ECIPAS
• Periodical title: The Journal of Medical Investigation
• No. or year of volume/issue: 70 1-2
• Volume: 70
• Issue: 1-2
• Pages: 251-259
• ISSN (Periodical Title): ISSN : 1349-6867; ISSN : 1343-1420
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-23
• Dissertation Number: 甲第3702号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Epidermoid cyst in intrapancreatic accessory spleen; imaging mass spectrometry; lipid excretion; Pbx1; Tlx1
• Target Audience: 一般
• Note (General): Background : Epidermoid cysts in intrapancreatic accessory spleen (ECIPAS) are a rare lesion. Its pathogenesis, including the origin of cystic epithelium, is not well established. We aimed to elucidate new aspects of the pathological features of ECIPAS to clarify its pathogenesis. Methods : Six cases of ECIPAS were included in this study. As well as histopathological analysis, to elucidate the features and nature of cystic epithelial cells, immunohistochemical analysis including Pbx1 and Tlx1 and imaging mass spectrometry was performed. Results : Histologically, the cysts were covered by either monolayered or multilayered epithelium. Immunohistochemistry revealed that the epithelial cells in multilayered epithelium exhibited different attributes between the basal and superficial layers. Few epithelial cells had abundant clear cytoplasm and were immunohistochemically positive for adipophilin, suggesting lipid-excreting function. The intracystic fluid contained cholesterol clefts and foamy macrophages, and imaging mass spectrometry revealed the accumulation of lipids. Immunohistochemical analysis indicated that the epithelial cells were positive for Pbx1 in some cases. Conclusion : Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2152/jmi.70.251
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/118205/20230511175750671675/k3702_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118205/20230511175750968782/k3702_review.pdf fulltext

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