Plasma Heparin Cofactor II Activity Is Inversely Associated with Hepatic Fibrosis of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

• 資料種別: 博士論文
• タイトル: Plasma Heparin Cofactor II Activity Is Inversely Associated with Hepatic Fibrosis of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
• 著者・編者: Hara, Tomoyo; Uemoto, Ryoko; Sekine, Akiko; Mitsui, Yukari; Masuda, Shiho; Yamagami, Hiroki; Kurahashi, Kiyoe; Yoshida, Sumiko; Otoda, Toshiki; Yuasa, Tomoyuki; Kuroda, Akio; Ikeda, Yasumasa; Endo, Itsuro; Honda, Soichi; Yoshimoto, Katsuhiko; Kondo, Akira; Tamaki, Toshiaki; Matsumoto, Toshio; Matsuhisa, Munehide; Abe, Masahiro; Aihara, Ken-ichi
• 著者標目: Hara, Tomoyo; Uemoto, Ryoko; Sekine, Akiko; Mitsui, Yukari; Masuda, Shiho; Yamagami, Hiroki; Kurahashi, Kiyoe; Yoshida, Sumiko; Otoda, Toshiki; Yuasa, Tomoyuki; Kuroda, Akio; Ikeda, Yasumasa; Endo, Itsuro; Honda, Soichi; Yoshimoto, Katsuhiko; Kondo, Akira; Tamaki, Toshiaki; Matsumoto, Toshio; Matsuhisa, Munehide; Abe, Masahiro; Aihara, Ken-ichi
• 出版事項: Japan Atherosclerosis Society
• 出版年月日等: 2023-08-01
• 出版年（W3CDTF）: 2023-08-01
• 並列タイトル等: 血漿Heparin Cofactor II活性は２型糖尿病患者における非アルコール性脂肪性肝疾患肝線維化と逆相関する; Heparin Cofactor II and NAFLD in T2DM
• タイトル（掲載誌）: Journal of Atherosclerosis and Thrombosis
• 巻号年月日等（掲載誌）: 30 8
• 掲載巻: 30
• 掲載号: 8
• 掲載ページ: 871-883
• ISSN（掲載誌）: ISSN : 1880-3873; ISSN : 1340-3478
• 授与機関名: 徳島大学
• 授与年月日: 2023-03-23
• 報告番号: 甲第3689号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: ヘパリンコファクターII; プロテアーゼ活性化受容体; 糖尿病; NAFLD; 横断研究; Thrombin; Protease-activated receptors; Heparin cofactor II; T2DM
• 対象利用者: 一般
• 一般注記: Aims: Thrombin exerts various pathophysiological functions by activating protease-activated receptors (PARs), and thrombin-induced activation of PARs promotes the development of non-alcoholic fatty liver disease (NAFLD). Since heparin cofactor II (HCII) specifically inactivates thrombin action, we hypothesized that plasma HCII activity correlates with the severity of NAFLD. Methods: A cross-sectional study was conducted. Plasma HCII activity and noninvasive clinical markers of hepatic fibrosis including fibrosis-4 (FIB-4) index, NAFLD fibrosis score (NFS) and aspartate aminotransferase-to-platelet ratio index (APRI) were determined in 305 Japanese patients with type 2 diabetes mellitus (T2DM). The relationships between plasma HCII activity and the clinical markers were statistically evaluated. Results: Multiple regression analysis including confounding factors showed that plasma HCII activity independently contributed to decreases in FIB-4 index (p＜0.001), NFS (p＜0.001) and APRI (p=0.004). In addition, logistic regression analysis for the prevalence of advanced hepatic fibrosis defined by the cutoff points of the clinical scores showed that plasma HCII activity was the sole and common negative factor for prevalence of advanced hepatic fibrosis (FIB-4 index: p=0.002, NFS: p=0.026 and APRI: p=0.012). Conclusions: Plasma HCII activity was inversely associated with clinical hepatic fibrosis indices including FIB-4 index, NFS and APRI and with the prevalence of advanced hepatic fibrosis in patients with T2DM. The results suggest that HCII can serve as a novel biomarker for assessment of hepatic fibrosis of NAFLD in patients with T2DM.
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.( https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja )
• 関連情報（DOI）: 10.5551/jat.63752
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/118258/20230524154222998916/k3689_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118258/20230524154223308426/k3689_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118258/20230524154223661255/k3689_fulltext.pdf fulltext