Plasma Heparin Cofactor II Activity Is Inversely Associated with Hepatic Fibrosis of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus

• Material Type: 博士論文
• Title: Plasma Heparin Cofactor II Activity Is Inversely Associated with Hepatic Fibrosis of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
• Author/Editor: Hara, Tomoyo; Uemoto, Ryoko; Sekine, Akiko; Mitsui, Yukari; Masuda, Shiho; Yamagami, Hiroki; Kurahashi, Kiyoe; Yoshida, Sumiko; Otoda, Toshiki; Yuasa, Tomoyuki; Kuroda, Akio; Ikeda, Yasumasa; Endo, Itsuro; Honda, Soichi; Yoshimoto, Katsuhiko; Kondo, Akira; Tamaki, Toshiaki; Matsumoto, Toshio; Matsuhisa, Munehide; Abe, Masahiro; Aihara, Ken-ichi
• Author Heading: Hara, Tomoyo; Uemoto, Ryoko; Sekine, Akiko; Mitsui, Yukari; Masuda, Shiho; Yamagami, Hiroki; Kurahashi, Kiyoe; Yoshida, Sumiko; Otoda, Toshiki; Yuasa, Tomoyuki; Kuroda, Akio; Ikeda, Yasumasa; Endo, Itsuro; Honda, Soichi; Yoshimoto, Katsuhiko; Kondo, Akira; Tamaki, Toshiaki; Matsumoto, Toshio; Matsuhisa, Munehide; Abe, Masahiro; Aihara, Ken-ichi
• Publication, Distribution, etc.: Japan Atherosclerosis Society
• Publication Date: 2023-08-01
• Publication Date (W3CDTF): 2023-08-01
• Alternative Title: 血漿Heparin Cofactor II活性は２型糖尿病患者における非アルコール性脂肪性肝疾患肝線維化と逆相関する; Heparin Cofactor II and NAFLD in T2DM
• Periodical title: Journal of Atherosclerosis and Thrombosis
• No. or year of volume/issue: 30 8
• Volume: 30
• Issue: 8
• Pages: 871-883
• ISSN (Periodical Title): ISSN : 1880-3873; ISSN : 1340-3478
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-23
• Dissertation Number: 甲第3689号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: ヘパリンコファクターII; プロテアーゼ活性化受容体; 糖尿病; NAFLD; 横断研究; Thrombin; Protease-activated receptors; Heparin cofactor II; T2DM
• Target Audience: 一般
• Note (General): Aims: Thrombin exerts various pathophysiological functions by activating protease-activated receptors (PARs), and thrombin-induced activation of PARs promotes the development of non-alcoholic fatty liver disease (NAFLD). Since heparin cofactor II (HCII) specifically inactivates thrombin action, we hypothesized that plasma HCII activity correlates with the severity of NAFLD. Methods: A cross-sectional study was conducted. Plasma HCII activity and noninvasive clinical markers of hepatic fibrosis including fibrosis-4 (FIB-4) index, NAFLD fibrosis score (NFS) and aspartate aminotransferase-to-platelet ratio index (APRI) were determined in 305 Japanese patients with type 2 diabetes mellitus (T2DM). The relationships between plasma HCII activity and the clinical markers were statistically evaluated. Results: Multiple regression analysis including confounding factors showed that plasma HCII activity independently contributed to decreases in FIB-4 index (p＜0.001), NFS (p＜0.001) and APRI (p=0.004). In addition, logistic regression analysis for the prevalence of advanced hepatic fibrosis defined by the cutoff points of the clinical scores showed that plasma HCII activity was the sole and common negative factor for prevalence of advanced hepatic fibrosis (FIB-4 index: p=0.002, NFS: p=0.026 and APRI: p=0.012). Conclusions: Plasma HCII activity was inversely associated with clinical hepatic fibrosis indices including FIB-4 index, NFS and APRI and with the prevalence of advanced hepatic fibrosis in patients with T2DM. The results suggest that HCII can serve as a novel biomarker for assessment of hepatic fibrosis of NAFLD in patients with T2DM.
• Access Restrictions: インターネット公開
• Rights (production): This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.( https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja )
• Related Material (DOI): 10.5551/jat.63752
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/118258/20230524154222998916/k3689_abstract.pdf fulltext

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