Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period

• 資料種別: 博士論文
• タイトル: Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period
• 著者・編者: Okikawa, Shohei; Kashihara, Hideya; Shimada, Mitsuo; Yoshikawa, Kozo; Tokunaga, Takuya; Nishi, Masaaki; Takasu, Chie; Wada, Yuma; Yoshimoto, Toshiaki
• 著者標目: Okikawa, Shohei; Kashihara, Hideya; Shimada, Mitsuo; Yoshikawa, Kozo; Tokunaga, Takuya; Nishi, Masaaki; Takasu, Chie; Wada, Yuma; Yoshimoto, Toshiaki
• 出版事項: Springer Nature
• 出版年月日等: 2023-02-01
• 出版年（W3CDTF）: 2023-02-01
• 並列タイトル等: 十二指腸空腸バイパスの糖尿病に対する術後早期における効果
• タイトル（掲載誌）: Scientific Reports
• 巻号年月日等（掲載誌）: 13
• 掲載巻: 13
• 掲載ページ: 1856-
• ISSN（掲載誌）: ISSN : 2045-2322
• 授与機関名: 徳島大学
• 授与年月日: 2023-10-26
• 報告番号: 甲第3763号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Duodenal-jejunal bypass (DJB); Type2 diabetes mellitus (T2DM); Glucose transporter 1 (GLUT1); sodium-glucose cotransporter 1 (SGLT1); Goto-kakizaki rat
• 対象利用者: 一般
• 一般注記: Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• 関連情報（DOI）: 10.1038/s41598-023-28923-3
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/118744/20231120114731903835/k3763_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118744/2023112011473224475/k3763_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118744/20231120114732187007/k3763_fulltext.pdf fulltext