Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period

• Material Type: 博士論文
• Title: Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period
• Author/Editor: Okikawa, Shohei; Kashihara, Hideya; Shimada, Mitsuo; Yoshikawa, Kozo; Tokunaga, Takuya; Nishi, Masaaki; Takasu, Chie; Wada, Yuma; Yoshimoto, Toshiaki
• Author Heading: Okikawa, Shohei; Kashihara, Hideya; Shimada, Mitsuo; Yoshikawa, Kozo; Tokunaga, Takuya; Nishi, Masaaki; Takasu, Chie; Wada, Yuma; Yoshimoto, Toshiaki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2023-02-01
• Publication Date (W3CDTF): 2023-02-01
• Alternative Title: 十二指腸空腸バイパスの糖尿病に対する術後早期における効果
• Periodical title: Scientific Reports
• No. or year of volume/issue: 13
• Volume: 13
• Pages: 1856-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 徳島大学
• Date Granted: 2023-10-26
• Dissertation Number: 甲第3763号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Duodenal-jejunal bypass (DJB); Type2 diabetes mellitus (T2DM); Glucose transporter 1 (GLUT1); sodium-glucose cotransporter 1 (SGLT1); Goto-kakizaki rat
• Target Audience: 一般
• Note (General): Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
• Access Restrictions: インターネット公開
• Rights (production): This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• Related Material (DOI): 10.1038/s41598-023-28923-3
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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http://repo.lib.tokushima-u.ac.jp/files/public/11/118744/20231120114731903835/k3763_abstract.pdf fulltext

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