Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part : focusing on NMDA receptor

• 資料種別: 博士論文
• タイトル: Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part : focusing on NMDA receptor
• 著者・編者: Kanayama, Hiroyuki; Tominaga, Takashi; Tominaga, Yoko; Kato, Nobuo; Yoshimura, Hiroshi
• 著者標目: Kanayama, Hiroyuki; Tominaga, Takashi; Tominaga, Yoko; Kato, Nobuo; Yoshimura, Hiroshi
• 出版事項: BioMed Central/Springer Nature
• 出版年月日等: 2024-03-12
• 出版年（W3CDTF）: 2024-03-12
• 並列タイトル等: 大脳皮質体性感覚野の口腔領域における局所回路オシレーションに対するGABAB受容体の作用 : NMDA受容体に焦点を当てて
• タイトル（掲載誌）: The Journal of Physiological Sciences
• 巻号年月日等（掲載誌）: 74
• 掲載巻: 74
• 掲載ページ: 16-
• ISSN（掲載誌）: ISSN : 1880-6546; ISSN : 1880-6562
• 授与機関名: 徳島大学
• 授与年月日: 2024-03-14
• 報告番号: 甲第3789号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Caffeine; GABAB receptor; NMDA receptor; Network oscillation; Oral somatosensory cortex; Voltage-sensitive dye
• 対象利用者: 一般
• 一般注記: The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosensory cortex (OSC), focusing on NMDA receptors. Neural oscillation at the frequency of 8–10 Hz was elicited in rat brain slices after caffeine application. Oscillations comprised a non-NMDA receptor-dependent initial phase and a later NMDA receptor-dependent oscillatory phase, with the oscillator located in the upper layer of the OSC. Baclofen was applied to investigate the actions of GABAB receptors. The later NMDA receptor-dependent oscillatory phase completely disappeared, but the initial phase did not. These results suggest that GABAB receptors mainly act on NMDA receptor, in which metabotropic actions of GABAB receptors may contribute to the attenuation of NMDA receptor activities. A regulatory system for network oscillation involving GABAB receptors may be present in the OSC.
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• 関連情報（DOI）: 10.1186/s12576-024-00911-w
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/119318/20240426153155399759/k3789_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119318/20240426153155495234/k3789_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119318/20240516111845982281/k3789_fulltext.pdf fulltext