Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part : focusing on NMDA receptor

• Material Type: 博士論文
• Title: Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part : focusing on NMDA receptor
• Author/Editor: Kanayama, Hiroyuki; Tominaga, Takashi; Tominaga, Yoko; Kato, Nobuo; Yoshimura, Hiroshi
• Author Heading: Kanayama, Hiroyuki; Tominaga, Takashi; Tominaga, Yoko; Kato, Nobuo; Yoshimura, Hiroshi
• Publication, Distribution, etc.: BioMed Central/Springer Nature
• Publication Date: 2024-03-12
• Publication Date (W3CDTF): 2024-03-12
• Alternative Title: 大脳皮質体性感覚野の口腔領域における局所回路オシレーションに対するGABAB受容体の作用 : NMDA受容体に焦点を当てて
• Periodical title: The Journal of Physiological Sciences
• No. or year of volume/issue: 74
• Volume: 74
• Pages: 16-
• ISSN (Periodical Title): ISSN : 1880-6546; ISSN : 1880-6562
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-14
• Dissertation Number: 甲第3789号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Caffeine; GABAB receptor; NMDA receptor; Network oscillation; Oral somatosensory cortex; Voltage-sensitive dye
• Target Audience: 一般
• Note (General): The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosensory cortex (OSC), focusing on NMDA receptors. Neural oscillation at the frequency of 8–10 Hz was elicited in rat brain slices after caffeine application. Oscillations comprised a non-NMDA receptor-dependent initial phase and a later NMDA receptor-dependent oscillatory phase, with the oscillator located in the upper layer of the OSC. Baclofen was applied to investigate the actions of GABAB receptors. The later NMDA receptor-dependent oscillatory phase completely disappeared, but the initial phase did not. These results suggest that GABAB receptors mainly act on NMDA receptor, in which metabotropic actions of GABAB receptors may contribute to the attenuation of NMDA receptor activities. A regulatory system for network oscillation involving GABAB receptors may be present in the OSC.
• Access Restrictions: インターネット公開
• Rights (production): This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• Related Material (DOI): 10.1186/s12576-024-00911-w
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

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