The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells

• 資料種別: 博士論文
• タイトル: The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells
• 著者・編者: Tawara, Hiroaki; Tsunematsu, Takaaki; Kitajima, Shojiro; Nagao, Ruka; Matsuzawa, Shigefumi; Otsuka, Kunihiro; Ushio, Aya; Ishimaru, Naozumi
• 著者標目: Tawara, Hiroaki; Tsunematsu, Takaaki; Kitajima, Shojiro; Nagao, Ruka; Matsuzawa, Shigefumi; Otsuka, Kunihiro; Ushio, Aya; Ishimaru, Naozumi
• 出版事項: Elsevier
• 出版年月日等: 2024-03-06
• 出版年（W3CDTF）: 2024-03-06
• 並列タイトル等: 染色体パッセンジャー複合体構成因子であるBorealinの非古典的な機能は扁平上皮癌においてSurvivinの安定化を介して乳酸の産生を促進する
• タイトル（掲載誌）: Biochemical and Biophysical Research Communications
• 巻号年月日等（掲載誌）: 706
• 掲載巻: 706
• 掲載ページ: 149741-
• ISSN（掲載誌）: ISSN : 0006-291X; ISSN : 1090-2104
• 授与機関名: 徳島大学
• 授与年月日: 2024-03-22
• 報告番号: 甲第3825号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Chromosome passenger complex; Borealin; Survivin; glycolysis; squamous cell carcinoma
• 対象利用者: 一般
• 一般注記: The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is known to confer chemoresistance. This study showed that the overexpression of borealin, a CPC component, stabilized survivin protein depending on its interaction with survivin. Unexpectedly, the accumulation of survivin by borealin overexpression did not affect the well-characterized functions of survivin, such as chemoresistance and cell proliferation. Interestingly, the overexpression of borealin promoted lactate production but not the overexpression of the deletion mutant that lacks the ability to bind to survivin. Consistent with these findings, the expression levels of glycolysis-related genes were enhanced in borealin-overexpressing cancer cells. Meanwhile, the overexpression of survivin alone did not promote lactate production. Overall, the accumulation of the borealin-survivin complex promoted glycolysis in squamous cell carcinoma cells. This mechanism may contribute to cancer progression via excessive lactate production.
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.bbrc.2024.149741
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/119377/2024052211283249867/k3825_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119377/20240522112832197547/k3825_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119377/20240527093327518760/k3825_fulltext.pdf fulltext