The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells

• Material Type: 博士論文
• Title: The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells
• Author/Editor: Tawara, Hiroaki; Tsunematsu, Takaaki; Kitajima, Shojiro; Nagao, Ruka; Matsuzawa, Shigefumi; Otsuka, Kunihiro; Ushio, Aya; Ishimaru, Naozumi
• Author Heading: Tawara, Hiroaki; Tsunematsu, Takaaki; Kitajima, Shojiro; Nagao, Ruka; Matsuzawa, Shigefumi; Otsuka, Kunihiro; Ushio, Aya; Ishimaru, Naozumi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2024-03-06
• Publication Date (W3CDTF): 2024-03-06
• Alternative Title: 染色体パッセンジャー複合体構成因子であるBorealinの非古典的な機能は扁平上皮癌においてSurvivinの安定化を介して乳酸の産生を促進する
• Periodical title: Biochemical and Biophysical Research Communications
• No. or year of volume/issue: 706
• Volume: 706
• Pages: 149741-
• ISSN (Periodical Title): ISSN : 0006-291X; ISSN : 1090-2104
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-22
• Dissertation Number: 甲第3825号
• Degree Type: 博士（歯学）
• Text Language Code: eng
• Subject Heading: Chromosome passenger complex; Borealin; Survivin; glycolysis; squamous cell carcinoma
• Target Audience: 一般
• Note (General): The chromosome passenger complex (CPC) is a kinase complex formed by Aurora B, borealin, survivin and inner centromere protein (INCENP). The CPC is active during mitosis and contributes to proper chromosome segregation via the phosphorylation of various substrates. Overexpression of each CPC component has been reported in most cancers. However, its significance remains unclear, as only survivin is known to confer chemoresistance. This study showed that the overexpression of borealin, a CPC component, stabilized survivin protein depending on its interaction with survivin. Unexpectedly, the accumulation of survivin by borealin overexpression did not affect the well-characterized functions of survivin, such as chemoresistance and cell proliferation. Interestingly, the overexpression of borealin promoted lactate production but not the overexpression of the deletion mutant that lacks the ability to bind to survivin. Consistent with these findings, the expression levels of glycolysis-related genes were enhanced in borealin-overexpressing cancer cells. Meanwhile, the overexpression of survivin alone did not promote lactate production. Overall, the accumulation of the borealin-survivin complex promoted glycolysis in squamous cell carcinoma cells. This mechanism may contribute to cancer progression via excessive lactate production.
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.bbrc.2024.149741
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 徳島大学 : 徳島大学機関リポジトリ

Table of Contents

http://repo.lib.tokushima-u.ac.jp/files/public/11/119377/2024052211283249867/k3825_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119377/20240522112832197547/k3825_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119377/20240527093327518760/k3825_fulltext.pdf fulltext