The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs

• 資料種別: 博士論文
• タイトル: The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs
• 著者・編者: 香川, 真貴子
• 著者標目: 香川, 真貴子
• 並列タイトル等: ヒト歯肉線維芽細胞におけるMatrix metalloproteinase-3産生に及ぼすフェニトインの影響
• 授与機関名: 大阪歯科大学
• 授与年月日: 2016-03-11
• 報告番号: 甲第777号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Phenytoin; Matrix metalloproteinase-3; Human gingival fibroblast
• 対象利用者: 一般
• 一般注記: Special care must be taken in the orthodontic treatment of patients who are medicating with phenytoin, which has a side effect of gingival overgrowth. However, the mechanism of this side effect is not yet known in detail.Gingival overgrowth is termed hatred by inflammation, and it has been reported that when inflammation occurs during phenytoin treatment the movement of the teeth is delayed. Therefore, in the present study, it was decided to investigate the mechanisms of phenytoin by focusing on matrix metalloproteinases (MMPs) that are expressed as a result of inflammation.In this study, we demonstrated that the production of MMP-3 in TNF-α-stimulated Human gingival fibroblasts (HGFs) is suppressed by phenytoin. In addition, phenytoin suppressed the phosphorylation of NFκB in TNF-α stimulated HGFs. These results suggested that phenytoin stimulation regulated the production of MMP-3 in inflammatory HGFs, and that phenythoin stimulation involves NFκB signaling.; 2015
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: CC BY-NC-ND
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=113&item_no=1&attribute_id=20&file_no=2 fulltext

https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=113&item_no=1&attribute_id=20&file_no=1 fulltext