The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs

Material type: 博士論文

Author: 香川, 真貴子

Publisher: -

Publication date: -

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 大阪歯科大学,博士（歯学）

View All

Notes on use

Note (General)：: Special care must be taken in the orthodontic treatment of patients who are medicating with phenytoin, which has a side effect of gingival overgrowth....

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Osaka Dental University Academic Repository
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Osaka Dental University Academic Repository

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: The Effect of Phenytoin on the Matrix Metalloprotease-3 Production in HGFs
Author/Editor: 香川, 真貴子
Author Heading: 香川, 真貴子
Alternative Title: ヒト歯肉線維芽細胞におけるMatrix metalloproteinase-3産生に及ぼすフェニトインの影響
Degree grantor/type: 大阪歯科大学
Date Granted: 2016-03-11
Dissertation Number: 甲第777号
Degree Type: 博士（歯学）
Text Language Code: eng
Subject Heading: Phenytoin
Matrix metalloproteinase-3
Human gingival fibroblast
Target Audience: 一般
Note (General): Special care must be taken in the orthodontic treatment of patients who are medicating with phenytoin, which has a side effect of gingival overgrowth. However, the mechanism of this side effect is not yet known in detail.Gingival overgrowth is termed hatred by inflammation, and it has been reported that when inflammation occurs during phenytoin treatment the movement of the teeth is delayed. Therefore, in the present study, it was decided to investigate the mechanisms of phenytoin by focusing on matrix metalloproteinases (MMPs) that are expressed as a result of inflammation.In this study, we demonstrated that the production of MMP-3 in TNF-α-stimulated Human gingival fibroblasts (HGFs) is suppressed by phenytoin. In addition, phenytoin suppressed the phosphorylation of NFκB in TNF-α stimulated HGFs. These results suggested that phenytoin stimulation regulated the production of MMP-3 in inflammatory HGFs, and that phenythoin stimulation involves NFκB signaling.
2015
Source: fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=113&item_no=1&attribute_id=20&file_no=2
fulltext
https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=113&item_no=1&attribute_id=20&file_no=1
Access Restrictions: インターネット公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 大阪歯科大学 : 大阪歯科大学学術リポジトリ