Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy

• 資料種別: 博士論文
• タイトル: Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy
• 著者・編者: Okada, koji; Ota, Toyosaku; Iida, Junzo; Kishimoto, Naoko; Kishimoto, Toshifumi
• 著者標目: Okada, koji; Ota, Toyosaku; Iida, Junzo; Kishimoto, Naoko; Kishimoto, Toshifumi
• 出版事項: Elsevier / Press
• 出版年月日等: 2013-06-03
• 出版年（W3CDTF）: 2013-06-03
• 並列タイトル等: 近赤外線スペクトロスコピィで測定された成人強迫性障害における前頭前野の活動性の低下
• タイトル（掲載誌）: Progress in neuro-psychopharmacology & biological psychiatry
• 巻号年月日等（掲載誌）: 43
• 掲載巻: 43
• 掲載ページ: 7-13
• ISSN（掲載誌）: ISSN : 0278-5846
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2013-05-29
• 報告番号: 甲第599号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: obsessive-compulsive disorder; near-infrared spectroscopy; functional neuroimaging study; prefrontal hemodynamic response; Stroop color-word task
• 対象利用者: 一般
• 一般注記: type:Thesis; Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Here we used NIRS to investigate neurobiological function in 12 patients with OCD and 12 age- and sex-matched, healthy control subjects. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 sec, during performance of a Stroop color-word task, using 24-channel NIRS. Oxy-Hb changes in the prefrontal cortex of the OCD group were significantly smaller than those in the control group, especially in the left lateral prefrontal cortex. These results suggest that patients with OCD have reduced prefrontal hemodynamic responses as measured by NIRS.; 博士（医学）・甲第599号・平成25年5月29日; Copyright © 2012 Elsevier Inc. All rights reserved.; identifier:Progress in neuro-psychopharmacology & biological psychiatry Vol.43 p.7-13 (2013 Jun); identifier:02785846; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2587; identifier:Progress in neuro-psychopharmacology & biological psychiatry, 43: 7-13
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.pnpbp.2012.11.013
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2587/6/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2587/7/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2587/13/03%e6%9c%ac%e6%96%87.pdf fulltext