Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy

• Material Type: 博士論文
• Title: Lower prefrontal activity in adults with obsessive-compulsive disorder as measured by near-infrared spectroscopy
• Author/Editor: Okada, koji; Ota, Toyosaku; Iida, Junzo; Kishimoto, Naoko; Kishimoto, Toshifumi
• Author Heading: Okada, koji; Ota, Toyosaku; Iida, Junzo; Kishimoto, Naoko; Kishimoto, Toshifumi
• Publication, Distribution, etc.: Elsevier / Press
• Publication Date: 2013-06-03
• Publication Date (W3CDTF): 2013-06-03
• Alternative Title: 近赤外線スペクトロスコピィで測定された成人強迫性障害における前頭前野の活動性の低下
• Periodical title: Progress in neuro-psychopharmacology & biological psychiatry
• No. or year of volume/issue: 43
• Volume: 43
• Pages: 7-13
• ISSN (Periodical Title): ISSN : 0278-5846
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-05-29
• Dissertation Number: 甲第599号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: obsessive-compulsive disorder; near-infrared spectroscopy; functional neuroimaging study; prefrontal hemodynamic response; Stroop color-word task
• Target Audience: 一般
• Note (General): type:Thesis; Recent developments in near-infrared spectroscopy (NIRS) have enabled the non-invasive elucidation of the neurobiological underpinnings of psychiatric disorders. Functional neuroimaging studies in human patients have suggested that the frontal cortex and subcortical structures may play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Here we used NIRS to investigate neurobiological function in 12 patients with OCD and 12 age- and sex-matched, healthy control subjects. The relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 sec, during performance of a Stroop color-word task, using 24-channel NIRS. Oxy-Hb changes in the prefrontal cortex of the OCD group were significantly smaller than those in the control group, especially in the left lateral prefrontal cortex. These results suggest that patients with OCD have reduced prefrontal hemodynamic responses as measured by NIRS.; 博士（医学）・甲第599号・平成25年5月29日; Copyright © 2012 Elsevier Inc. All rights reserved.; identifier:Progress in neuro-psychopharmacology & biological psychiatry Vol.43 p.7-13 (2013 Jun); identifier:02785846; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2587; identifier:Progress in neuro-psychopharmacology & biological psychiatry, 43: 7-13
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2587/6/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2587/7/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2587/13/03%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.pnpbp.2012.11.013
• Periodical Title (NCID): AA10532839; https://ci.nii.ac.jp/ncid/AA10532839
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU