In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser

• 資料種別: 博士論文
• タイトル: In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser
• 著者・編者: Yasui, Takeshi; Yonetsu, Makoto; Tanaka, Ryosuke; Tanaka, Yuji; Fukushima, Shu-ichiro; Yamashita, Toyonobu; Ogura, Yuki; Hirao, Tetsuji; Murota, Hiroyuki; Araki, Tsutomu
• 著者標目: Yasui, Takeshi; Yonetsu, Makoto; Tanaka, Ryosuke; Tanaka, Yuji; Fukushima, Shu-ichiro; Yamashita, Toyonobu; Ogura, Yuki; Hirao, Tetsuji; Murota, Hiroyuki; Araki, Tsutomu
• 出版事項: SPIE--the International Society for Optical Engineering
• 出版年月日等: 2013-03
• 出版年（W3CDTF）: 2013-03
• 並列タイトル等: 1250nm帯モード同期クロム・フォルステライトレーザーを光源とした第2高調波発生光顕微鏡によるヒト顔皮膚の老化性真皮コラーゲン構造変化のその場観察
• タイトル（掲載誌）: Journal of biomedical optics
• 巻号年月日等（掲載誌）: 18 3
• 掲載巻: 18
• 掲載号: 3
• 掲載ページ: 31108-1-31108-10
• ISSN（掲載誌）: ISSN : 1083-3668
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2013-05-29
• 報告番号: 乙第1311号
• 学位: 博士（医学）
• 本文の言語コード: und
• 件名標目: nonlinear microscopy; second harmonic generation; collagen; dermatology; intrinsic aging; photoaging; tissue; dermis
• 対象利用者: 一般
• 一般注記: type:Thesis; In vivo visualization of human skin aging is demonstrated using a Cr:Forsterite (Cr:F) laser-based, collagen-sensitive second harmonic generation (SHG) microscope. The deep penetration into human skin, as well as the specific sensitivity to collagen molecules, achieved by this microscope enables us to clearly visualize age-related structural changes of collagen fiber in the reticular dermis. Here we investigated intrinsic aging and/or photoaging in the male facial skin. Young subjects show dense distributions of thin collagen fibers, whereas elderly subjects show coarse distributions of thick collagen fibers. Furthermore, a comparison of SHG images between young and elderly subjects with and without a recent life history of excessive sun exposure show that a combination of photoaging with intrinsic aging significantly accelerates skin aging. We also perform image analysis based on two-dimensional Fourier transformation of the SHG images and extracted an aging parameter for human skin. The in vivo collagen-sensitive SHG microscope will be a powerful tool in fields such as cosmeceutical sciences and anti-aging dermatology.; 博士（医学）・乙第1311号・平成25年5月29日; identifier:Journal of biomedical optics Vol.18 No.3 p.31108(1-10); identifier:10833668; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2589; identifier:Journal of biomedical optics, 18(3): 31108-1-31108-10
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1117/1.JBO.18.3.031108
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2589/4/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2589/3/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2589/1/03%e6%9c%ac%e6%96%87.pdf fulltext