In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser

• Material Type: 博士論文
• Title: In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser
• Author/Editor: Yasui, Takeshi; Yonetsu, Makoto; Tanaka, Ryosuke; Tanaka, Yuji; Fukushima, Shu-ichiro; Yamashita, Toyonobu; Ogura, Yuki; Hirao, Tetsuji; Murota, Hiroyuki; Araki, Tsutomu
• Author Heading: Yasui, Takeshi; Yonetsu, Makoto; Tanaka, Ryosuke; Tanaka, Yuji; Fukushima, Shu-ichiro; Yamashita, Toyonobu; Ogura, Yuki; Hirao, Tetsuji; Murota, Hiroyuki; Araki, Tsutomu
• Publication, Distribution, etc.: SPIE--the International Society for Optical Engineering
• Publication Date: 2013-03
• Publication Date (W3CDTF): 2013-03
• Alternative Title: 1250nm帯モード同期クロム・フォルステライトレーザーを光源とした第2高調波発生光顕微鏡によるヒト顔皮膚の老化性真皮コラーゲン構造変化のその場観察
• Periodical title: Journal of biomedical optics
• No. or year of volume/issue: 18 3
• Volume: 18
• Issue: 3
• Pages: 31108-1-31108-10
• ISSN (Periodical Title): ISSN : 1083-3668
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-05-29
• Dissertation Number: 乙第1311号
• Degree Type: 博士（医学）
• Text Language Code: und
• Subject Heading: nonlinear microscopy; second harmonic generation; collagen; dermatology; intrinsic aging; photoaging; tissue; dermis
• Target Audience: 一般
• Note (General): type:Thesis; In vivo visualization of human skin aging is demonstrated using a Cr:Forsterite (Cr:F) laser-based, collagen-sensitive second harmonic generation (SHG) microscope. The deep penetration into human skin, as well as the specific sensitivity to collagen molecules, achieved by this microscope enables us to clearly visualize age-related structural changes of collagen fiber in the reticular dermis. Here we investigated intrinsic aging and/or photoaging in the male facial skin. Young subjects show dense distributions of thin collagen fibers, whereas elderly subjects show coarse distributions of thick collagen fibers. Furthermore, a comparison of SHG images between young and elderly subjects with and without a recent life history of excessive sun exposure show that a combination of photoaging with intrinsic aging significantly accelerates skin aging. We also perform image analysis based on two-dimensional Fourier transformation of the SHG images and extracted an aging parameter for human skin. The in vivo collagen-sensitive SHG microscope will be a powerful tool in fields such as cosmeceutical sciences and anti-aging dermatology.; 博士（医学）・乙第1311号・平成25年5月29日; identifier:Journal of biomedical optics Vol.18 No.3 p.31108(1-10); identifier:10833668; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2589; identifier:Journal of biomedical optics, 18(3): 31108-1-31108-10
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1117/1.JBO.18.3.031108
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2589/4/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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