Neurocognitive functioning in patients with first-episode schizophrenia 1 year from onset in comparison with patients 5 years from onset.

• 資料種別: 博士論文
• タイトル: Neurocognitive functioning in patients with first-episode schizophrenia 1 year from onset in comparison with patients 5 years from onset.
• 著者・編者: Matsuda, Yasuhiro; Sato, Sayaka; Hatsuse, Norifumi; Watanabe, Yukako; Kishimoto, Toshifumi; Ikebuchi, Emi
• 著者標目: Matsuda, Yasuhiro; Sato, Sayaka; Hatsuse, Norifumi; Watanabe, Yukako; Kishimoto, Toshifumi; Ikebuchi, Emi
• 出版事項: Informa Healthcare
• 出版年月日等: 2014-01
• 出版年（W3CDTF）: 2014-01
• 並列タイトル等: 統合失調症初発エピソードの認知機能障害の経過と発症5 年経過群との比較
• タイトル（掲載誌）: International journal of psychiatry in clinical practice
• 巻号年月日等（掲載誌）: 18 1
• 掲載巻: 18
• 掲載号: 1
• 掲載ページ: 63-69
• ISSN（掲載誌）: ISSN : 1365-1501
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2014-03-17
• 報告番号: 甲第610号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Schizophrenia; first-episode; neurocognitive functioning; prospective study; social functioning
• 対象利用者: 一般
• 一般注記: type:Thesis; OBJECTIVE: The course of neurocognitive deficits in schizophrenia has not yet been established. Therefore, we followed patients with first-episode schizophrenia to verify the course of these deficits. METHODS:In Study 1, tests of neurocognitive functioning were administered to patients with first-episode schizophrenia (FE group) every 6 months. Of the 26 patients who completed the baseline assessment, 19 completed a 6-month follow-up, and 13 completed a 1-year follow-up. In Study 2, 19 patients in FE group at 6-months when the neuropsychological measures was less influenced by psychotic symptoms and other patients who experienced schizophrenia 5-years earlier (5-year group) were compared. RESULTS:In Study 1, verbal memory, motor speed, and executive functions significantly improved at the 1-year follow-up. In Study 2, patients in 5-year group performed worse in verbal memory and executive functions than patients in FE at 6-month group, but marginally but significantly better in verbal fluency. CONCLUSIONS:Verbal memory, executive functions, and verbal fluency were significantly different between 5-year group and FE at 6-month group, and may indicate progression of schizophrenia. Executive functions may reflect the state of psychosis. Working memory and processing speed which did not change significantly from onset are needed to verify the course in further research.; 博士（医学）・甲610号・平成26年3月17日; identifier:International journal of psychiatry in clinical practice Vol.18 No.1 p.63-69; identifier:13651501; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2689; identifier:International journal of psychiatry in clinical practice, 18(1): 63-69
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3109/13651501.2013.845220
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2689/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2689/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2689/6/03%e6%9c%ac%e6%96%87.pdf fulltext