Neurocognitive functioning in patients with first-episode schizophrenia 1 year from onset in comparison with patients 5 years from onset.

• Material Type: 博士論文
• Title: Neurocognitive functioning in patients with first-episode schizophrenia 1 year from onset in comparison with patients 5 years from onset.
• Author/Editor: Matsuda, Yasuhiro; Sato, Sayaka; Hatsuse, Norifumi; Watanabe, Yukako; Kishimoto, Toshifumi; Ikebuchi, Emi
• Author Heading: Matsuda, Yasuhiro; Sato, Sayaka; Hatsuse, Norifumi; Watanabe, Yukako; Kishimoto, Toshifumi; Ikebuchi, Emi
• Publication, Distribution, etc.: Informa Healthcare
• Publication Date: 2014-01
• Publication Date (W3CDTF): 2014-01
• Alternative Title: 統合失調症初発エピソードの認知機能障害の経過と発症5 年経過群との比較
• Periodical title: International journal of psychiatry in clinical practice
• No. or year of volume/issue: 18 1
• Volume: 18
• Issue: 1
• Pages: 63-69
• ISSN (Periodical Title): ISSN : 1365-1501
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2014-03-17
• Dissertation Number: 甲第610号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Schizophrenia; first-episode; neurocognitive functioning; prospective study; social functioning
• Target Audience: 一般
• Note (General): type:Thesis; OBJECTIVE: The course of neurocognitive deficits in schizophrenia has not yet been established. Therefore, we followed patients with first-episode schizophrenia to verify the course of these deficits. METHODS:In Study 1, tests of neurocognitive functioning were administered to patients with first-episode schizophrenia (FE group) every 6 months. Of the 26 patients who completed the baseline assessment, 19 completed a 6-month follow-up, and 13 completed a 1-year follow-up. In Study 2, 19 patients in FE group at 6-months when the neuropsychological measures was less influenced by psychotic symptoms and other patients who experienced schizophrenia 5-years earlier (5-year group) were compared. RESULTS:In Study 1, verbal memory, motor speed, and executive functions significantly improved at the 1-year follow-up. In Study 2, patients in 5-year group performed worse in verbal memory and executive functions than patients in FE at 6-month group, but marginally but significantly better in verbal fluency. CONCLUSIONS:Verbal memory, executive functions, and verbal fluency were significantly different between 5-year group and FE at 6-month group, and may indicate progression of schizophrenia. Executive functions may reflect the state of psychosis. Working memory and processing speed which did not change significantly from onset are needed to verify the course in further research.; 博士（医学）・甲610号・平成26年3月17日; identifier:International journal of psychiatry in clinical practice Vol.18 No.1 p.63-69; identifier:13651501; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2689; identifier:International journal of psychiatry in clinical practice, 18(1): 63-69
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3109/13651501.2013.845220
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2689/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2689/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2689/6/03%e6%9c%ac%e6%96%87.pdf fulltext