Expression of REG Ⅲ and prognosis in head and neck cancer

• 資料種別: 博士論文
• タイトル: Expression of REG Ⅲ and prognosis in head and neck cancer
• 著者・編者: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• 著者標目: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• 出版事項: National Hellenic Research Foundation / Spandidos
• 出版年月日等: 2013-08
• 出版年（W3CDTF）: 2013-08
• 並列タイトル等: 頭頸部癌におけるREG Ⅲ の発現と予後
• タイトル（掲載誌）: Oncology reports
• 巻号年月日等（掲載誌）: 30 2
• 掲載巻: 30
• 掲載号: 2
• 掲載ページ: 573-578
• ISSN（掲載誌）: ISSN : 1021-335X
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-03-16
• 報告番号: 甲第625号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: REG Ⅲ; head and neck cancer; chemoradiosensitivity
• 対象利用者: 一般
• 一般注記: type:Thesis; Identification of a reliable biomarker for predicting prognosis in head and neck cancers is highly desirable and has long been sought. There have been several reports that members of the regenerating gene (REG) family are highly expressed in chronic inflammation and in tumors of the digestive organs. In addition, it has been described in several reports that REG expression is associated with the progression of digestive cancers. In the present study, we evaluated the effect of REG expression on the prognosis of hypopharyngeal cancer. We investigated 37 cases with hypopharyngeal squamous cell carcinoma, determined REG mRNA expression, which is easily detected in formalin-fixed paraffin-embedded tissues using the real-time reverse transcriptase-polymerase chain reaction method, and evaluated the survival rate using the Kaplan-Meier method. According to these results, REG Ⅲ mRNA expression was significantly associated with prolonged survival. Therefore, we constructed hypopharyngeal cancer cell lines transfected with REG Ⅲ and assessed the cell proliferation and chemosensitivity and/or radiosensitivity in vitro. Cells transfected with REG Ⅲ exhibited significantly lower cell proliferation and higher chemosensitivity and/or radiosensitivity compared with the control cells. These data suggest that REG Ⅲ may be a reliable biomarker of prognosis in hypopharyngeal cancer. This is the first report concerning the association of REG Ⅲ expression and the prognosis of head and neck squamous cell carcinoma including hypopharyngeal cancer.; 博士（医学）・甲第625号・平成27年3月16日; 本文のリンク：http://dx.doi.org/10.3892/or.2013.2521; Copyright © Spandidos Publications 2014; identifier:Oncology reports Vol.30 No.2 p.573-578; identifier:1021335X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2937; identifier:Oncology reports, 30(2): 573-578
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3892/or.2013.2521
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2937/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2937/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2937/3/03%e6%9c%ac%e6%96%87.pdf fulltext