Expression of REG Ⅲ and prognosis in head and neck cancer

• Material Type: 博士論文
• Title: Expression of REG Ⅲ and prognosis in head and neck cancer
• Author/Editor: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• Author Heading: Masui, Takashi; Ota, Ichiro; Itaya-Hironaka, Asako; Takeda, Maiko; Kasai, Takahiko; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Mikami, Shinji; Yane, Katsunari; Takasawa, Shin; Hosoi, Hiroshi
• Publication, Distribution, etc.: National Hellenic Research Foundation / Spandidos
• Publication Date: 2013-08
• Publication Date (W3CDTF): 2013-08
• Alternative Title: 頭頸部癌におけるREG Ⅲ の発現と予後
• Periodical title: Oncology reports
• No. or year of volume/issue: 30 2
• Volume: 30
• Issue: 2
• Pages: 573-578
• ISSN (Periodical Title): ISSN : 1021-335X
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-03-16
• Dissertation Number: 甲第625号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: REG Ⅲ; head and neck cancer; chemoradiosensitivity
• Target Audience: 一般
• Note (General): type:Thesis; Identification of a reliable biomarker for predicting prognosis in head and neck cancers is highly desirable and has long been sought. There have been several reports that members of the regenerating gene (REG) family are highly expressed in chronic inflammation and in tumors of the digestive organs. In addition, it has been described in several reports that REG expression is associated with the progression of digestive cancers. In the present study, we evaluated the effect of REG expression on the prognosis of hypopharyngeal cancer. We investigated 37 cases with hypopharyngeal squamous cell carcinoma, determined REG mRNA expression, which is easily detected in formalin-fixed paraffin-embedded tissues using the real-time reverse transcriptase-polymerase chain reaction method, and evaluated the survival rate using the Kaplan-Meier method. According to these results, REG Ⅲ mRNA expression was significantly associated with prolonged survival. Therefore, we constructed hypopharyngeal cancer cell lines transfected with REG Ⅲ and assessed the cell proliferation and chemosensitivity and/or radiosensitivity in vitro. Cells transfected with REG Ⅲ exhibited significantly lower cell proliferation and higher chemosensitivity and/or radiosensitivity compared with the control cells. These data suggest that REG Ⅲ may be a reliable biomarker of prognosis in hypopharyngeal cancer. This is the first report concerning the association of REG Ⅲ expression and the prognosis of head and neck squamous cell carcinoma including hypopharyngeal cancer.; 博士（医学）・甲第625号・平成27年3月16日; 本文のリンク：http://dx.doi.org/10.3892/or.2013.2521; Copyright © Spandidos Publications 2014; identifier:Oncology reports Vol.30 No.2 p.573-578; identifier:1021335X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2937; identifier:Oncology reports, 30(2): 573-578
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3892/or.2013.2521
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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