Gelatin Sealing Sheet for Arterial Hemostasis and Anti-adhesion in Vascular Surgery: a Dog Model Study.

• 資料種別: 博士論文
• タイトル: Gelatin Sealing Sheet for Arterial Hemostasis and Anti-adhesion in Vascular Surgery: a Dog Model Study.
• 著者・編者: Hu, Yinghao; Yamashita, Keigo; Tabayashi, Nobuoki; Abe, Takehisa; Hayata, Yoshihiro; Hirose, Tomoaki; Hiraga, Shun; Tojo, Takashi; Suzuki, Shuko; Ikada, Yoshito; Taniguchi, Shigeki
• 著者標目: Hu, Yinghao; Yamashita, Keigo; Tabayashi, Nobuoki; Abe, Takehisa; Hayata, Yoshihiro; Hirose, Tomoaki; Hiraga, Shun; Tojo, Takashi; Suzuki, Shuko; Ikada, Yoshito; Taniguchi, Shigeki
• 出版事項: IOS press
• 出版年月日等: 2014-09-09
• 出版年（W3CDTF）: 2014-09-09
• 並列タイトル等: 心臓血管外科領域におけるゼラチンシートの止血効果、癒着防止効果の検討
• タイトル（掲載誌）: Bio-medical materials and engineering
• 巻号年月日等（掲載誌）: 25 2
• 掲載巻: 25
• 掲載号: 2
• 掲載ページ: 157-168
• ISSN（掲載誌）: ISSN : 0959-2989
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-03-16
• 報告番号: 甲第632号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: gelatin; fibrin glue; surgical sealant; anti-adhesion; postoperative adhesions
• 対象利用者: 一般
• 一般注記: type:Thesis; BACKGROUND:The bi1ayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE:To examine the feasibility of gelatin sealing sheets using a canine aterial hemorrhage mode1. METHODS:In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in rats. For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of dogs were pricked with syringe needle to make as mall hole, and a gelatin(i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop bleeding (n=8). After discontinuation of the bleeding, the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS:From the degradation study, 4h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, bleeding from the needle hole on canine femoral arteries was effectively stopped. Postoperative adhesions and inflammation at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS:The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing postoperative adhesions.; 博士（医学）・甲第632号・平成27年3月16日; Copyright ©2015 IOS Press; identifier:Bio-medical materials and engineering Vol.25 No.2 p.157-168 (2015); identifier:09592989; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2963; identifier:Bio-medical materials and engineering, 25(2): 157-168
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3233/bme-151266
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2963/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2963/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2963/3/03%e6%9c%ac%e6%96%87.pdf fulltext