Gelatin Sealing Sheet for Arterial Hemostasis and Anti-adhesion in Vascular Surgery: a Dog Model Study.

• Material Type: 博士論文
• Title: Gelatin Sealing Sheet for Arterial Hemostasis and Anti-adhesion in Vascular Surgery: a Dog Model Study.
• Author/Editor: Hu, Yinghao; Yamashita, Keigo; Tabayashi, Nobuoki; Abe, Takehisa; Hayata, Yoshihiro; Hirose, Tomoaki; Hiraga, Shun; Tojo, Takashi; Suzuki, Shuko; Ikada, Yoshito; Taniguchi, Shigeki
• Author Heading: Hu, Yinghao; Yamashita, Keigo; Tabayashi, Nobuoki; Abe, Takehisa; Hayata, Yoshihiro; Hirose, Tomoaki; Hiraga, Shun; Tojo, Takashi; Suzuki, Shuko; Ikada, Yoshito; Taniguchi, Shigeki
• Publication, Distribution, etc.: IOS press
• Publication Date: 2014-09-09
• Publication Date (W3CDTF): 2014-09-09
• Alternative Title: 心臓血管外科領域におけるゼラチンシートの止血効果、癒着防止効果の検討
• Periodical title: Bio-medical materials and engineering
• No. or year of volume/issue: 25 2
• Volume: 25
• Issue: 2
• Pages: 157-168
• ISSN (Periodical Title): ISSN : 0959-2989
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-03-16
• Dissertation Number: 甲第632号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: gelatin; fibrin glue; surgical sealant; anti-adhesion; postoperative adhesions
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND:The bi1ayer gelatin sealing sheet was developed as a safe, effective, easy-to-handle and low-cost hemostatic agent. OBJECTIVE:To examine the feasibility of gelatin sealing sheets using a canine aterial hemorrhage mode1. METHODS:In vivo degradation of gelatin sealing sheets was examined by implanting subcutaneously in rats. For the hemostatic and anti-adhesion efficacy investigations, femoral arteries of dogs were pricked with syringe needle to make as mall hole, and a gelatin(i.e. experimental group) or fibrin glue sealing sheet (i.e. control group) was applied on the hole to stop bleeding (n=8). After discontinuation of the bleeding, the skin incisions were closed and re-examined 4 weeks postoperatively. RESULTS:From the degradation study, 4h thermally treated gelatin sheet which degraded within 3 weeks in vivo was chosen for the further hemostatic study. In all cases of gelatin and fibrin glue sealing sheets, bleeding from the needle hole on canine femoral arteries was effectively stopped. Postoperative adhesions and inflammation at the site in the experimental group were significantly less than those in the control group (P<0.01 for adhesion scores). CONCLUSIONS:The gelatin sealing sheet was found to be as effective as the fibrin glue sealing sheet as a surgical hemostatic agent, and more effective in preventing postoperative adhesions.; 博士（医学）・甲第632号・平成27年3月16日; Copyright ©2015 IOS Press; identifier:Bio-medical materials and engineering Vol.25 No.2 p.157-168 (2015); identifier:09592989; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2963; identifier:Bio-medical materials and engineering, 25(2): 157-168
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3233/bme-151266
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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