Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors.

• 資料種別: 博士論文
• タイトル: Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors.
• 著者・編者: Ochi, Tomoko; Taoka, Toshiaki; Matsuda, Ryosuke; Sakamoto, Masahiko; Akashi, Toshiaki; Tamamoto, Ttetsuo; Sugimoto, Tadashi; Sakaguchi, Hiroshi; Hasegawa, Masatoshi; Nakase, Hiroyuki; Kichikawa, Kimihiko
• 著者標目: Ochi, Tomoko; Taoka, Toshiaki; Matsuda, Ryosuke; Sakamoto, Masahiko; Akashi, Toshiaki; Tamamoto, Ttetsuo; Sugimoto, Tadashi; Sakaguchi, Hiroshi; Hasegawa, Masatoshi; Nakase, Hiroyuki; Kichikawa, Kimihiko
• 出版事項: 日本磁気共鳴医学会(Japan Society of Magnetic Resonance in Medicine)
• 出版年月日等: 2014-12-22
• 出版年（W3CDTF）: 2014-12-22
• 並列タイトル等: 転移性脳腫瘍の倍量造影剤投与における、分割投与と単回投与の病変描出能の比較
• タイトル（掲載誌）: Magnetic resonance in medical sciences
• 巻号年月日等（掲載誌）: 13 4
• 掲載巻: 13
• 掲載号: 4
• 掲載ページ: 221-229
• ISSN（掲載誌）: ISSN : 1347-3182
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-03-16
• 報告番号: 乙第1356号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: contrast-enhanced MRI; double-dose contrast study; metastatic brain tumor; number of injections
• 対象利用者: 一般
• 一般注記: type:Thesis; PURPOSE: As stereotactic radiotherapy (SRT) becomes widespread, precise information including number, location, and margin of lesions is required when magnetic resonance (MR) imaging of brain metastasis is performed. We compare methods using 2 separate injections and a single injection for the administration of a double dose of contrast medium for contrastenhanced MR imaging. MATERIALS AND METHODS: We divided 40 patients with brain metastasis into 2 groups of 20 patients. Group A received 2 separate injections (0.2 + 0.2 mL/kg) of contrast medium (gadoteridol); Group B received a single injection of the same total dose (0.4 mL/kg). Group A underwent spin echo (SE) T1-weighted imaging (T1WI) and magnetization prepared rapid acquisition with gradient echo sequence (MPRAGE) after each injection, and Group B underwent the same MR studies at the same timing as Group A. We evaluated the number, signal-to-noise ratio (SNR), diameter, margin delineation, and volume of lesions and compared them between early and delayed studies by the 2 methods. RESULTS: The number of detected lesions was largest in delayed studies of MPRAGE in both groups. The SNR of the lesions was statistically lower in early studies of Group A than other studies. Delayed studies of Group B showed statistically better margin delineation than other studies on both SE-T1WI and MPRAGE studies. Diameter and enhanced volume were statistically significantly larger on delayed phase than early phase in both groups. CONCLUSION: Use of a single injection of double-dose contrast medium and longer delay time may improve margin delineation of lesions for the study of brain metastasis. Enhanced volume was larger on delayed phase, and it may influence selection of therapeutic strategy.; 博士（医学）・乙第1356号・平成27年3月16日; Copyright © 2014 by Japanese Society for Magnetic Resonance in Medicine; 著作権は日本磁気共鳴医学会に帰属; 日本磁気共鳴医学会及び著者（共著者も含む）の許諾を得て登録; identifier:Magnetic resonance in medical sciences Vol.13 No.4 p.221-229; identifier:13473182; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2975; identifier:Magnetic resonance in medical sciences, 13(4): 221-229
• 一次資料へのリンクURL: comment：fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2975/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2975/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2975/3/03%e6%9c%ac%e6%96%87.pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2463/mrms.2013-0068
• 掲載誌（NCID）: AA11648770; https://ci.nii.ac.jp/ncid/AA11648770
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU