Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors.

• Material Type: 博士論文
• Title: Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors.
• Author/Editor: Ochi, Tomoko; Taoka, Toshiaki; Matsuda, Ryosuke; Sakamoto, Masahiko; Akashi, Toshiaki; Tamamoto, Ttetsuo; Sugimoto, Tadashi; Sakaguchi, Hiroshi; Hasegawa, Masatoshi; Nakase, Hiroyuki; Kichikawa, Kimihiko
• Author Heading: Ochi, Tomoko; Taoka, Toshiaki; Matsuda, Ryosuke; Sakamoto, Masahiko; Akashi, Toshiaki; Tamamoto, Ttetsuo; Sugimoto, Tadashi; Sakaguchi, Hiroshi; Hasegawa, Masatoshi; Nakase, Hiroyuki; Kichikawa, Kimihiko
• Publication, Distribution, etc.: 日本磁気共鳴医学会(Japan Society of Magnetic Resonance in Medicine)
• Publication Date: 2014-12-22
• Publication Date (W3CDTF): 2014-12-22
• Alternative Title: 転移性脳腫瘍の倍量造影剤投与における、分割投与と単回投与の病変描出能の比較
• Periodical title: Magnetic resonance in medical sciences
• No. or year of volume/issue: 13 4
• Volume: 13
• Issue: 4
• Pages: 221-229
• ISSN (Periodical Title): ISSN : 1347-3182
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2015-03-16
• Dissertation Number: 乙第1356号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: contrast-enhanced MRI; double-dose contrast study; metastatic brain tumor; number of injections
• Target Audience: 一般
• Note (General): type:Thesis; PURPOSE: As stereotactic radiotherapy (SRT) becomes widespread, precise information including number, location, and margin of lesions is required when magnetic resonance (MR) imaging of brain metastasis is performed. We compare methods using 2 separate injections and a single injection for the administration of a double dose of contrast medium for contrastenhanced MR imaging. MATERIALS AND METHODS: We divided 40 patients with brain metastasis into 2 groups of 20 patients. Group A received 2 separate injections (0.2 + 0.2 mL/kg) of contrast medium (gadoteridol); Group B received a single injection of the same total dose (0.4 mL/kg). Group A underwent spin echo (SE) T1-weighted imaging (T1WI) and magnetization prepared rapid acquisition with gradient echo sequence (MPRAGE) after each injection, and Group B underwent the same MR studies at the same timing as Group A. We evaluated the number, signal-to-noise ratio (SNR), diameter, margin delineation, and volume of lesions and compared them between early and delayed studies by the 2 methods. RESULTS: The number of detected lesions was largest in delayed studies of MPRAGE in both groups. The SNR of the lesions was statistically lower in early studies of Group A than other studies. Delayed studies of Group B showed statistically better margin delineation than other studies on both SE-T1WI and MPRAGE studies. Diameter and enhanced volume were statistically significantly larger on delayed phase than early phase in both groups. CONCLUSION: Use of a single injection of double-dose contrast medium and longer delay time may improve margin delineation of lesions for the study of brain metastasis. Enhanced volume was larger on delayed phase, and it may influence selection of therapeutic strategy.; 博士（医学）・乙第1356号・平成27年3月16日; Copyright © 2014 by Japanese Society for Magnetic Resonance in Medicine; 著作権は日本磁気共鳴医学会に帰属; 日本磁気共鳴医学会及び著者（共著者も含む）の許諾を得て登録; identifier:Magnetic resonance in medical sciences Vol.13 No.4 p.221-229; identifier:13473182; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2975; identifier:Magnetic resonance in medical sciences, 13(4): 221-229
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2463/mrms.2013-0068
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2975/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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