Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer.

• 資料種別: 博士論文
• タイトル: Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer.
• 著者・編者: Ito, Masahiro; Migita, Kazuhiro; Matsumoto, Sohei; Wakatsuki, Kohei; Tanaka, Tetsuya; Kunishige, Tomohiro; Nakade, Hiroshi; Nakatani, Mitsuhiro; Nakajima, Yoshiyuki
• 著者標目: Ito, Masahiro; Migita, Kazuhiro; Matsumoto, Sohei; Wakatsuki, Kohei; Tanaka, Tetsuya; Kunishige, Tomohiro; Nakade, Hiroshi; Nakatani, Mitsuhiro; Nakajima, Yoshiyuki
• 出版事項: Spandidos Publications
• 出版年月日等: 2017-05
• 出版年（W3CDTF）: 2017-05
• 並列タイトル等: ヒト胃癌患者におけるtripartite motif 32の過剰発現は予後不良に関連する
• タイトル（掲載誌）: Oncology letters
• 巻号年月日等（掲載誌）: 13 5
• 掲載巻: 13
• 掲載号: 5
• 掲載ページ: 3131-3138
• ISSN（掲載誌）: ISSN : 1792-1074
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2017-06-28
• 報告番号: 乙第1402号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: enzyme 3 ubiquitin ligase; gastric cancer; hematogenous recurrence; prognostic factor; tripartite motif 32
• 対象利用者: 一般
• 一般注記: type:Thesis; Tripartite motif protein (TRIM) 32 belongs to the TRIM family, which is composed of RING finger, B-box and coiled-coil domains. TRIM32 has been reported to function as an enzyme 3 ubiquitin ligase and is overexpressed in numerous types of cancer. The present study evaluated the clinical significance of TRIM32 expression levels in gastric cancer. The current study also investigated the TRIM32 expression levels in 142 patients with gastric cancer using immunohistochemistry and examined its clinical importance and potential as a prognostic marker. Furthermore, the function of TRIM32 was examined in vitro. High TRIM32 expression levels were detected in gastric cancer tissues. The postoperative overall and relapse-free survival rates were significantly reduced in patients with tumors with high levels of TRIM32 expression compared with those with tumors expressing low levels of TRIM32. Tumors expressing high levels of TRIM32 were associated with an increased risk of postoperative recurrence, particularly hematogenous recurrence. Multivariate analysis identified TRIM32 status as an independent prognostic factor. Furthermore, TRIM32 gene silencing induced apoptosis and inhibited the proliferation of gastric cancer cells in vitro. Therefore, TRIM32 expression levels may be of potential prognostic value in gastric cancer.; 博士（医学）・乙第1402号・平成29年6月28日; Copyright © Spandidos Publications 2017. All rights reserved.; The Spandidos Publications link is available at " http://dx.doi.org/10.3892/ol.2017.5806 "; identifier:Oncology letters Vol.13 No.5 p.3131-3138 (2017 May); identifier:17921074; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3348; identifier:Oncology letters, 13(5): 3131-3138
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3892/ol.2017.5806
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3348/1/01%e4%b9%991402%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3348/2/02%e4%b9%991402%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3348/6/03%e4%b9%991402%e6%9c%ac%e6%96%87.pdf fulltext