Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer.

• Material Type: 博士論文
• Title: Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer.
• Author/Editor: Ito, Masahiro; Migita, Kazuhiro; Matsumoto, Sohei; Wakatsuki, Kohei; Tanaka, Tetsuya; Kunishige, Tomohiro; Nakade, Hiroshi; Nakatani, Mitsuhiro; Nakajima, Yoshiyuki
• Author Heading: Ito, Masahiro; Migita, Kazuhiro; Matsumoto, Sohei; Wakatsuki, Kohei; Tanaka, Tetsuya; Kunishige, Tomohiro; Nakade, Hiroshi; Nakatani, Mitsuhiro; Nakajima, Yoshiyuki
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2017-05
• Publication Date (W3CDTF): 2017-05
• Alternative Title: ヒト胃癌患者におけるtripartite motif 32の過剰発現は予後不良に関連する
• Periodical title: Oncology letters
• No. or year of volume/issue: 13 5
• Volume: 13
• Issue: 5
• Pages: 3131-3138
• ISSN (Periodical Title): ISSN : 1792-1074
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2017-06-28
• Dissertation Number: 乙第1402号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: enzyme 3 ubiquitin ligase; gastric cancer; hematogenous recurrence; prognostic factor; tripartite motif 32
• Target Audience: 一般
• Note (General): type:Thesis; Tripartite motif protein (TRIM) 32 belongs to the TRIM family, which is composed of RING finger, B-box and coiled-coil domains. TRIM32 has been reported to function as an enzyme 3 ubiquitin ligase and is overexpressed in numerous types of cancer. The present study evaluated the clinical significance of TRIM32 expression levels in gastric cancer. The current study also investigated the TRIM32 expression levels in 142 patients with gastric cancer using immunohistochemistry and examined its clinical importance and potential as a prognostic marker. Furthermore, the function of TRIM32 was examined in vitro. High TRIM32 expression levels were detected in gastric cancer tissues. The postoperative overall and relapse-free survival rates were significantly reduced in patients with tumors with high levels of TRIM32 expression compared with those with tumors expressing low levels of TRIM32. Tumors expressing high levels of TRIM32 were associated with an increased risk of postoperative recurrence, particularly hematogenous recurrence. Multivariate analysis identified TRIM32 status as an independent prognostic factor. Furthermore, TRIM32 gene silencing induced apoptosis and inhibited the proliferation of gastric cancer cells in vitro. Therefore, TRIM32 expression levels may be of potential prognostic value in gastric cancer.; 博士（医学）・乙第1402号・平成29年6月28日; Copyright © Spandidos Publications 2017. All rights reserved.; The Spandidos Publications link is available at " http://dx.doi.org/10.3892/ol.2017.5806 "; identifier:Oncology letters Vol.13 No.5 p.3131-3138 (2017 May); identifier:17921074; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3348; identifier:Oncology letters, 13(5): 3131-3138
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3892/ol.2017.5806
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3348/1/01%e4%b9%991402%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3348/2/02%e4%b9%991402%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3348/6/03%e4%b9%991402%e6%9c%ac%e6%96%87.pdf fulltext